Phentolamine hydrochloride
Modify Date: 2025-08-25 19:43:53
Phentolamine hydrochloride structure
|
Common Name | Phentolamine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 73-05-2 | Molecular Weight | 317.813 | |
| Density | N/A | Boiling Point | 569ºC at 760 mmHg | |
| Molecular Formula | C17H20ClN3O | Melting Point | >230ºC(dec.) | |
| MSDS | Chinese USA | Flash Point | 297.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Phentolamine hydrochloridePhentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent[1]. |
| Name | 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Phentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent[1]. |
|---|---|
| Related Catalog | |
| References |
| Boiling Point | 569ºC at 760 mmHg |
|---|---|
| Melting Point | >230ºC(dec.) |
| Molecular Formula | C17H20ClN3O |
| Molecular Weight | 317.813 |
| Flash Point | 297.9ºC |
| Exact Mass | 317.129486 |
| PSA | 47.86000 |
| LogP | 3.40680 |
| Appearance of Characters | powder | white to off-white |
| InChIKey | TUEJFGFQYKDAPM-UHFFFAOYSA-N |
| SMILES | Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1.Cl |
| Storage condition | -20°C Freezer |
| Water Solubility | methanol: 10 mg/mL, clear, colorless |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S22-S24/25 |
| RIDADR | UN 3249 |
| WGK Germany | 3 |
| RTECS | SL0701000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
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Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4.
Br. J. Pharmacol. 171(23) , 5361-75, (2014) This study examined the role of the main vascular cAMP-hydrolysing phosphodiesterases (cAMP-PDE) in the regulation of basal vascular tone and relaxation of rat aorta mediated by β-adrenoceptors, follo... |
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Arc-Expressing Neuronal Ensembles Supporting Pattern Separation Require Adrenergic Activity in Anterior Piriform Cortex: An Exploration of Neural Constraints on Learning.
J. Neurosci. 35 , 14070-5, (2015) Arc ensembles in adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination training on highly similar odor pairs. Nonselective α- and β-adrenergic antagonists ... |
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Noradrenaline-mediated facilitation of inhibitory synaptic transmission in the dorsal horn of the rat spinal cord involves interlaminar communications.
Eur. J. Neurosci. 42 , 2654-65, (2015) In the dorsal horn of the spinal cord (DH), noradrenaline (NA) is released by axons originating from the locus coeruleus and induces spinal analgesia, the mechanisms of which are poorly understood. He... |
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation...
Source: NMMLSC
Target: ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens]
External Id: UNMCMD_ABCB6_1o_ValidationSet
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| 3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino)phenol Hydrochloride |
| 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline Hydrochloride |
| 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol Hydrochloride |
| m-(N-(2-Imidazolin-2-ylmethyl)-p-toluidino)phenol monohydrochloride |
| Fentolamine Hydrochloride |
| 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Hydrochloride |
| Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino), monohydrochloride |
| phentolamin hydrochloride |
| 3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol hydrochloride (1:1) |
| 2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride |
| EINECS 200-793-5 |
| Phentolamine hydrochloride |
| Phentolamine HCl |
| 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline Hydrochloride |
| Phenol, m-(N-(2-imidazolin-2-ylmethyl)-p-toluidino)-, monohydrochloride (8CI) |
| Prestwick_386 |
| phentolamine |
| MFCD00079268 |
| 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-p-toluidino]-phenol,hydrochloride |
| 50-60-2 (Parent) |
| 3-[N-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-toluidino]-phenol,Hydrochlorid |
| Regitine hydrochloride |
| Phenol, 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-, hydrochloride (1:1) |