89371-37-9

89371-37-9 structure
89371-37-9 structure
  • Name: Imidapril
  • Chemical Name: (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
  • CAS Number: 89371-37-9
  • Molecular Formula: C20H27N3O6
  • Molecular Weight: 405.44500
  • Catalog: API Circulatory system medication Antihypertensive drug
  • Create Date: 2018-07-19 17:20:45
  • Modify Date: 2024-01-13 20:22:12
  • Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research[1][2].

Name (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
Synonyms imidapril
(4S)-3-<(2S)-2-<N-<(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl>amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylic Acid
Hipertene (TN)
Imidapril [BAN:INN]
Imidaprilum
(S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid
Imidapril HCl
(4S)-1-methyl-3-{(2S)-2-[N-(1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylic acid
Imidapril (INN)
Imidaprilum [INN-Latin]
MFCD00870777
Description Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research[1][2].
Related Catalog
Target

MMP-9

References

[1]. Robinson DM, et al. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. Drugs. 2007;67(9):1359-78.

[2]. Yamamoto D, et al. Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9. J Mol Cell Cardiol. 2007 Dec;43(6):670-6.

Density 1.266 g/cm3
Boiling Point 577ºC at 760 mmHg
Melting Point 195-197°C
Molecular Formula C20H27N3O6
Molecular Weight 405.44500
Flash Point 302.8ºC
Exact Mass 405.19000
PSA 116.25000
LogP 1.14290
Storage condition -20°C Freezer
Risk Phrases R22:Harmful if swallowed. R34:Causes burns.
Safety Phrases S26-S36/37/39
RIDADR 1759
Packaging Group II
Hazard Class 8

~94%

89371-37-9 structure

89371-37-9

Literature: US4508727 A1, ; US 4508727 A

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89371-37-9 structure

89371-37-9

Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1374 - 1377
Precursor  0

DownStream  2