20426-12-4
20426-12-4 structure
- Name: 4-Hydroxychalcone
- Chemical Name: 4-hydroxychalcone
- CAS Number: 20426-12-4
- Molecular Formula: C15H12O2
- Molecular Weight: 224.25500
- Catalog: Chemical reagent Organic reagent Aromatic ketone
- Create Date: 2018-04-23 08:00:00
- Modify Date: 2026-07-01 19:41:20
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4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
| Name | 4-hydroxychalcone |
|---|---|
| Synonyms |
2-(4-Hydroxybenzal)acetophenone 2-(4-Hydroxybenzylidene)acetophenone
4-Hydroxychalcone, 10 mM in DMSO (E)-3-(4-hydroxyphenyl)-1-phenyl-2-propen-1-one 4-HYDROXYBENZYLIDENEACETOPHENONE 2-(4-Hydroxybenzal)acetophenone 3-(4-Hydroxyphenyl)-1-phenylprop-2-en-1-one, 4-(3-Oxo-3-phenylprop-1-en-1-yl)phenol MFCD00016488 (E)-3-(4-HYDROXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE HYDROXYCHALCONE,4 HYDROXYCHALCONE, 4 BENZYLIDENE-4-HYDROXYACETOPHENONE 2-(4-HYDROXYBENZAL)ACETOPHENONE 1-Phenyl-3-(4-hydroxyphenyl)-2-propene-1-one 3-(4-Hydroxyphenyl)-1-phenyl-2-propen-1-one 2-(4-Hydroxybenzylidene)acetophenone 2-(4-HYDROXYBENZYLIDENE)ACETOPHENONE 4-HYDROXYCHALCONE 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-phenyl P-Cinnamoylphenol NF-κB,4-Hydroxychalcone,4 Hydroxychalcone,4Hydroxychalcone,Nucle factor-κB,Nuclefactor-kappaB,Inhibitor,inhibit |
| Description | 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2]. |
|---|---|
| Related Catalog | |
| Target |
NF-κB[2] |
| References |
| Melting Point | 180-184 °C |
|---|---|
| Molecular Formula | C15H12O2 |
| Molecular Weight | 224.25500 |
| Exact Mass | 224.08400 |
| PSA | 37.30000 |
| LogP | 3.28830 |
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S37/39-S26 |
| RIDADR | 3077.0 |
| RTECS | UD1675000 |
| Hazard Class | 9.0 |
| HS Code | 2914501900 |
|
~97%
20426-12-4 |
| Literature: Rafiee, Ezzat; Rahimi, Farzaneh Journal of the Chilean Chemical Society, 2013 , vol. 58, # 3 p. 1926 - 1929 |
|
~99%
20426-12-4 |
| Literature: Gavande, Navnath S.; Kundu, Sonia; Badgujar, Naresh S.; Kaur, Gurmeet; Chakraborti, Asit K. Tetrahedron, 2006 , vol. 62, # 17 p. 4201 - 4204 |
|
~53%
20426-12-4 |
| Literature: Lin; Yu; Zhang Synthetic Communications, 1993 , vol. 23, # 3 p. 271 - 276 |
|
~35%
20426-12-4 |
| Literature: Graven, Anette; Grotli, Morten; Meldal, Morten Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 6 p. 955 - 962 |
| Precursor 5 | |
|---|---|
| DownStream 5 | |
| HS Code | 2914501900 |
|---|---|
| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |