4-Hydroxychalcone

Modify Date: 2024-01-02 10:32:43

4-Hydroxychalcone structure	Common Name	4-Hydroxychalcone
	CAS Number	20426-12-4	Molecular Weight	224.25500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₂O₂	Melting Point	180-184 °C
	MSDS	N/A	Flash Point	N/A

Use of 4-Hydroxychalcone

4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

Name	4-hydroxychalcone
Synonym	More Synonyms

Description	4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology
Target	NF-κB[2]
References	[1]. Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33. [2]. Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.

Melting Point	180-184 °C
Molecular Formula	C₁₅H₁₂O₂
Molecular Weight	224.25500
Exact Mass	224.08400
PSA	37.30000
LogP	3.28830

4-Hydroxychalcone MSDS(Chinese)

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S37/39-S26
RIDADR	3077.0
RTECS	UD1675000
Hazard Class	9.0
HS Code	2914501900

4-hydroxybenzal...

CAS#:123-08-0

Acetophenone

CAS#:98-86-2

~97%

4-Hydroxychalcone

CAS#:20426-12-4

Literature: Rafiee, Ezzat; Rahimi, Farzaneh Journal of the Chilean Chemical Society, 2013 , vol. 58, # 3 p. 1926 - 1929

4-Methoxychalcone

CAS#:22252-15-9

~99%

4-Hydroxychalcone

CAS#:20426-12-4

Literature: Gavande, Navnath S.; Kundu, Sonia; Badgujar, Naresh S.; Kaur, Gurmeet; Chakraborti, Asit K. Tetrahedron, 2006 , vol. 62, # 17 p. 4201 - 4204

4-hydroxybenzal...

CAS#:123-08-0

2-Bromoacetophenone

CAS#:70-11-1

~53%

4-Hydroxychalcone

CAS#:20426-12-4

Literature: Lin; Yu; Zhang Synthetic Communications, 1993 , vol. 23, # 3 p. 271 - 276

1-phenyl(trimet...

CAS#:13735-81-4

4-hydroxybenzal...

CAS#:123-08-0

~35%

4-Hydroxychalcone

CAS#:20426-12-4

Literature: Graven, Anette; Grotli, Morten; Meldal, Morten Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 6 p. 955 - 962

Precursor 5
CAS#:123-08-0 4-hydroxybenzal... CAS#:98-86-2 Acetophenone CAS#:22252-15-9 4-Methoxychalcone CAS#:70-11-1 2-Bromoacetophenone
CAS#:13735-81-4 1-phenyl(trimet...
DownStream 5
CAS#:614-47-1 (E)-Chalcone CAS#:123-08-0 4-hydroxybenzal... CAS#:98-86-2 Acetophenone CAS#:17791-25-2 3-(4-hydroxyphe...
CAS#:74629-69-9 4-(4-phenyl-2,3...

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

4-HYDROXYBENZYLIDENEACETOPHENONE

2-(4-Hydroxybenzylidene)acetophenone

2-(4-Hydroxybenzal)acetophenone

4-HYDROXYCHALCONE

MFCD00016488

HYDROXYCHALCONE,4

BENZYLIDENE-4-HYDROXYACETOPHENONE

4-Hydroxychalcone

Use of 4-Hydroxychalcone

Names

4-Hydroxychalcone Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms