4-Hydroxychalcone

Modify Date: 2025-08-23 23:23:57

4-Hydroxychalcone Structure
4-Hydroxychalcone structure
 Common Name 4-Hydroxychalcone
CAS Number 20426-12-4 Molecular Weight 224.25500
Density N/A Boiling Point N/A
Molecular Formula C15H12O2 Melting Point 180-184 °C
MSDS N/A Flash Point N/A

 Use of 4-Hydroxychalcone


4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

 Names

Name 4-hydroxychalcone
Synonym More Synonyms

 4-Hydroxychalcone Biological Activity

Description 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
Related Catalog
Target

NF-κB[2]

References

[1]. Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33.

[2]. Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.

 Chemical & Physical Properties

Melting Point 180-184 °C
Molecular Formula C15H12O2
Molecular Weight 224.25500
Exact Mass 224.08400
PSA 37.30000
LogP 3.28830

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S37/39-S26
RIDADR 3077.0
RTECS UD1675000
Hazard Class 9.0
HS Code 2914501900

 Customs

HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

4-HYDROXYBENZYLIDENEACETOPHENONE
2-(4-Hydroxybenzylidene)acetophenone
2-(4-Hydroxybenzal)acetophenone
4-HYDROXYCHALCONE
MFCD00016488
HYDROXYCHALCONE,4
BENZYLIDENE-4-HYDROXYACETOPHENONE
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