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6429-04-5

6429-04-5 structure

Name: Tetrahydropapaverine hydrochloride
Chemical Name: Tetrahydropapaverine hydrochloride
CAS Number: 6429-04-5
Molecular Formula: C₂₀H₂₆ClNO₄
Molecular Weight: 379.878
Catalog: Biochemical Inhibitor Metabolism Hydroxylase inhibitor
Create Date: 2018-06-18 15:01:22
Modify Date: 2025-08-25 13:34:05
Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons[1][2].

Name	Tetrahydropapaverine hydrochloride
Synonyms	EINECS 229-213-9 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1) Papaverine, 1,2,3,4-tetrahydro-, hydrochloride MFCD00035267 Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1)

Description	Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Koshimura I, et al. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res. 1997 Oct 31;773(1-2):108-16. [2]. Kim EI, et al. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 3;75(16):1949-57.

Density	1.12g/cm3
Boiling Point	475.8ºC at 760 mmHg
Melting Point	213-215ºC
Molecular Formula	C₂₀H₂₆ClNO₄
Molecular Weight	379.878
Flash Point	202.7ºC
Exact Mass	379.155029
PSA	53.53000
LogP	0.69750
Index of Refraction	1.549
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5070700

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratryl-, hydrochloride

CAS REGISTRY NUMBER :: 6429-04-5

LAST UPDATED :: 198310

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H25-N-O4.Cl-H

MOLECULAR WEIGHT :: 379.92

WISWESSER LINE NOTATION :: T66 CMT&J B1R CO1 DO1& HO1 IO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,200,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,200,1964

Hazard Codes	T: Toxic;
Risk Phrases	22
Safety Phrases	36
HS Code	2939190090

6957-27-3

~78%

6429-04-5

Literature: Yamada, Koichiro; Takeda, Mikio; Iwakuma, Takeo Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 2 p. 265 - 270

13074-31-2

~67%

6429-04-5

Literature: Sladkov, V. I.; Sazonova, N. M.; Grekova, G. S.; Kalistratov, S. G.; Sokolova, A. S.; et al. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 1 p. 47 - 50 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 1 p. 50 - 53

93-40-3

6429-04-5

Literature: European Journal of Medicinal Chemistry, , vol. 16, # 6 p. 515 - 524

139-76-4

6429-04-5

Literature: European Journal of Medicinal Chemistry, , vol. 16, # 6 p. 515 - 524

120-20-7

6429-04-5

Literature: European Journal of Medicinal Chemistry, , vol. 16, # 6 p. 515 - 524

Precursor 5
6957-27-3 13074-31-2 93-40-3 139-76-4
120-20-7
DownStream 4
64228-81-5 64228-78-0 13074-31-2 64493-21-6

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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