Tetrahydropapaverine hydrochloride

Modify Date: 2024-01-02 12:46:48

Tetrahydropapaverine hydrochloride Structure
Tetrahydropapaverine hydrochloride structure
 Common Name Tetrahydropapaverine hydrochloride
CAS Number 6429-04-5 Molecular Weight 379.878
Density 1.12g/cm3 Boiling Point 475.8ºC at 760 mmHg
Molecular Formula C20H26ClNO4 Melting Point 213-215ºC
MSDS N/A Flash Point 202.7ºC

 Use of Tetrahydropapaverine hydrochloride


Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons[1][2].

 Names

Name Tetrahydropapaverine hydrochloride
Synonym More Synonyms

 Tetrahydropapaverine hydrochloride Biological Activity

Description Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons[1][2].
Related Catalog
References

[1]. Koshimura I, et al. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res. 1997 Oct 31;773(1-2):108-16.

[2]. Kim EI, et al. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 3;75(16):1949-57.

 Chemical & Physical Properties

Density 1.12g/cm3
Boiling Point 475.8ºC at 760 mmHg
Melting Point 213-215ºC
Molecular Formula C20H26ClNO4
Molecular Weight 379.878
Flash Point 202.7ºC
Exact Mass 379.155029
PSA 53.53000
LogP 0.69750
Index of Refraction 1.549
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX5070700
CHEMICAL NAME :
Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratryl-, hydrochloride
CAS REGISTRY NUMBER :
6429-04-5
LAST UPDATED :
198310
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H25-N-O4.Cl-H
MOLECULAR WEIGHT :
379.92
WISWESSER LINE NOTATION :
T66 CMT&J B1R CO1 DO1& HO1 IO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,200,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,200,1964

 Safety Information

Hazard Codes T: Toxic;
Risk Phrases 22
Safety Phrases 36
HS Code 2939190090

 Synthetic Route

1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline structure

1-[(3,4-Dimetho...

CAS#:6957-27-3

~78%

Tetrahydropapaverine hydrochloride Structure

Tetrahydropapav...

CAS#:6429-04-5
Literature: Yamada, Koichiro; Takeda, Mikio; Iwakuma, Takeo Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 2 p. 265 - 270
(+/-)-Tetrahydropapaverine structure

(+/-)-Tetrahydr...

CAS#:13074-31-2

~67%

Tetrahydropapaverine hydrochloride Structure

Tetrahydropapav...

CAS#:6429-04-5
Literature: Sladkov, V. I.; Sazonova, N. M.; Grekova, G. S.; Kalistratov, S. G.; Sokolova, A. S.; et al. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 1 p. 47 - 50 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 1 p. 50 - 53
3,4-Dimethoxyphenylacetic acid structure

3,4-Dimethoxyph...

CAS#:93-40-3

~%

Tetrahydropapaverine hydrochloride Structure

Tetrahydropapav...

CAS#:6429-04-5
Literature: European Journal of Medicinal Chemistry, , vol. 16, # 6 p. 515 - 524
N-(3,4-Dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide structure

N-(3,4-Dimethox...

CAS#:139-76-4

~%

Tetrahydropapaverine hydrochloride Structure

Tetrahydropapav...

CAS#:6429-04-5
Literature: European Journal of Medicinal Chemistry, , vol. 16, # 6 p. 515 - 524
3,4-Dimethoxyphenethylamine structure

3,4-Dimethoxyph...

CAS#:120-20-7

~%

Tetrahydropapaverine hydrochloride Structure

Tetrahydropapav...

CAS#:6429-04-5
Literature: European Journal of Medicinal Chemistry, , vol. 16, # 6 p. 515 - 524

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

EINECS 229-213-9
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1)
Papaverine, 1,2,3,4-tetrahydro-, hydrochloride
MFCD00035267
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1)
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