118591-58-5
118591-58-5 structure
- Name: Tos-PEG2-OH
- Chemical Name: 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
- CAS Number: 118591-58-5
- Molecular Formula: C11H16O5S
- Molecular Weight: 260.30700
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2016-05-22 15:54:49
- Modify Date: 2026-08-08 09:40:18
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Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate |
|---|---|
| Synonyms |
Ethanol,2-(2-hydroxyethoxy)-,1-(4-Methylbenzenesulfonate)
Tos-PEG2-alcohol HO-PEG2-OTS Diethylene glycol p-toluenesulfonate 2-(2-hydroxyethoxy)ethyl p-methylbenzenesulfonate 2-(2-Hydroxyethoxy)ethyl 4-Methylbenzensulfonate diethylene glycol mono-p-toluenesulfonate 4Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) 2-(2-hydroxyethoxy)ethyl 4-methyl benzenesulfonate OH-PEG2-Tos Ts(OCH2CH2)2OH Tos-PEG2-OH/Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate) CAS_118-5 2-(2-{[(4-methylbenzene)sulfonyl]oxy}ethoxy)ethan-1-ol Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) peg2-tos toluene-4-sulfonic acid 2-(2-hydroxyethoxy)ethyl ester |
| Description | Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C11H16O5S |
|---|---|
| Molecular Weight | 260.30700 |
| Exact Mass | 260.07200 |
| PSA | 81.21000 |
| LogP | 1.79000 |
| Hazard Codes | Xn |
|---|---|
| HS Code | 2909499000 |
|
~97%
118591-58-5 |
| Literature: NATIONAL UNIVERSITY OF IRELAND, GALWAY Patent: US2011/217750 A1, 2011 ; Location in patent: Page/Page column 19 ; |
|
~%
118591-58-5 |
| Literature: Song, Rita; Kim, Yeong-Sang; Lee, Chong Ock; Sohn, Youn Soo Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1537 - 1540 |
| Precursor 3 | |
|---|---|
| DownStream 5 | |
![3,4-bis[2-(2-hydroxyethoxy)ethoxy]benzaldehyde structure](https://image.chemsrc.com/caspic/318/312610-28-9.png)
![2-[2-(4-phenylmethoxyphenoxy)ethoxy]ethanol structure](https://image.chemsrc.com/caspic/472/142879-00-3.png)
![N-[2-(2-hydroxyethoxy)ethyl]-4-methylbenzenesulfonamide structure](https://image.chemsrc.com/caspic/198/783-88-0.png)
![N,N-bis[2-(2-hydroxyethoxy)ethyl]-4-methylbenzenesulfonamide structure](https://image.chemsrc.com/caspic/045/72358-83-9.png)
| HS Code | 2909499000 |
|---|---|
| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |