DC Chemicals Limited
China
Product Name: Tos-PEG2-OH
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

118591-58-5

118591-58-5 structure

118591-58-5 structure

Name: Tos-PEG2-OH
Chemical Name: 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
CAS Number: 118591-58-5
Molecular Formula: C₁₁H₁₆O₅S
Molecular Weight: 260.30700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-05-22 15:54:49
Modify Date: 2024-01-11 18:58:51
Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
Synonyms	2-(2-hydroxyethoxy)ethyl p-methylbenzenesulfonate 2-(2-hydroxyethoxy)ethyl 4-methyl benzenesulfonate toluene-4-sulfonic acid 2-(2-hydroxyethoxy)ethyl ester 2-(2-{[(4-methylbenzene)sulfonyl]oxy}ethoxy)ethan-1-ol diethylene glycol mono-p-toluenesulfonate Ts(OCH2CH2)2OH Ethanol,2-(2-hydroxyethoxy)-,1-(4-Methylbenzenesulfonate)

Description	Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₁H₁₆O₅S
Molecular Weight	260.30700
Exact Mass	260.07200
PSA	81.21000
LogP	1.79000

Hazard Codes	Xn
HS Code	2909499000

98-59-9 structure

98-59-9

111-46-6 structure

111-46-6

~97%

118591-58-5 structure

118591-58-5

Literature: NATIONAL UNIVERSITY OF IRELAND, GALWAY Patent: US2011/217750 A1, 2011 ; Location in patent: Page/Page column 19 ;

111-77-3 structure

111-77-3

98-59-9 structure

98-59-9

~%

118591-58-5 structure

118591-58-5

Literature: Song, Rita; Kim, Yeong-Sang; Lee, Chong Ock; Sohn, Youn Soo Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1537 - 1540

Precursor 3
98-59-9 111-46-6 111-77-3
DownStream 5
139115-90-5 312610-28-9 142879-00-3 783-88-0
72358-83-9

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%