916979-34-5

916979-34-5 structure

Name: Allopurinol-d2
Chemical Name: 3,6-dideuterio-1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one
CAS Number: 916979-34-5
Molecular Formula: C₅H₂D₂N₄O
Molecular Weight: 138.12
Catalog: Signaling Pathways Metabolic Enzyme/Protease Xanthine Oxidase
Create Date: 2016-07-17 14:14:47
Modify Date: 2024-01-05 14:21:42
Allopurinol-d2 is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

Name	3,6-dideuterio-1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one
Synonyms	Allopurinol-d2 Caplenal-d2 Adenock-d2 Allopur-d2 Cellidrin-d2

Description	Allopurinol-d2 is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. [3]. Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472.

Hazard Codes	T+
RIDADR	2811.0