Allopurinol-d2

Modify Date: 2024-01-05 14:21:42

Allopurinol-d2 structure	Common Name	Allopurinol-d2
	CAS Number	916979-34-5	Molecular Weight	138.12
	Density	1.92g/cm3	Boiling Point	>222°C
	Molecular Formula	C₅H₂D₂N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	234.117°C

Use of Allopurinol-d2

Allopurinol-d2 is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

Name	3,6-dideuterio-1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one
Synonym	More Synonyms

Description	Allopurinol-d2 is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. [3]. Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472.

Density	1.92g/cm3
Boiling Point	>222°C
Molecular Formula	C₅H₂D₂N₄O
Molecular Weight	138.12
Flash Point	234.117°C
Exact Mass	138.05100
PSA	74.69000
LogP	0.05850

Hazard Codes	T+
RIDADR	2811.0

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Allopurinol-d2

Use of Allopurinol-d2

Names

Allopurinol-d2 Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms