300833-95-8

300833-95-8 structure

Name: GSA-10
Chemical Name: propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
CAS Number: 300833-95-8
Molecular Formula: C₂₆H₃₀N₂O₅
Molecular Weight: 450.527
Catalog: Signaling Pathways Stem Cell/Wnt Smo
Create Date: 2017-12-12 07:49:52
Modify Date: 2024-01-03 17:36:44
GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].

Name	propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
Synonyms	Propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl)carbonyl]amino}benzoate Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate GSA 10 4-[[(1-Hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester

Description	GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer
Target	Smoothened receptor[1]
References	[1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757. [2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport