300833-95-8
300833-95-8 structure
- Name: GSA-10
- Chemical Name: propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
- CAS Number: 300833-95-8
- Molecular Formula: C26H30N2O5
- Molecular Weight: 450.527
- Catalog: Signaling Pathways Stem Cell/Wnt Smo
- Create Date: 2017-12-12 07:49:52
- Modify Date: 2024-01-03 17:36:44
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GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].
| Name | propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate |
|---|---|
| Synonyms |
Propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl)carbonyl]amino}benzoate
Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate GSA 10 4-[[(1-Hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester |
| Description | GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Smoothened receptor[1] |
| References |
| Density | 1.240±0.06 g/cm3 |
|---|---|
| Boiling Point | 620.2±55.0 °C at 760 mmHg |
| Molecular Formula | C26H30N2O5 |
| Molecular Weight | 450.527 |
| Flash Point | 328.9±31.5 °C |
| Exact Mass | 450.215485 |
| PSA | 97.63000 |
| LogP | 5.79 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.610 |
| Water Solubility | Insuluble (4.1E-4 g/L) (25 ºC) |
