6100-05-6

6100-05-6 structure

Name: Hydroxycitric acid tripotassium hydrate
Chemical Name: Potassium citrate monohydrate
CAS Number: 6100-05-6
Molecular Formula: C₆H₇K₃O₈
Molecular Weight: 324.410
Catalog: Organic raw materials Organometallic compound Organic potassium
Create Date: 2018-02-04 08:00:00
Modify Date: 2024-01-04 17:39:30
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4].

Name	Potassium citrate monohydrate
Synonyms	MFCD00150442 EINECS 231-905-0 tripotassium,2-hydroxypropane-1,2,3-tricarboxylate,hydrate

Description	Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Metabolic Disease
In Vitro	Hydroxycitric acid shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Hydroxycitric acid can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Hydroxycitric acid suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells[2]. In chicken hepatocytes, Hydroxycitric acid decreases the accumulation of lipid droplets and accelerated energy metabolism. Hydroxycitric acid protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions[2].
In Vivo	Hydroxycitric acid (100-200 mg/kg) treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Hydroxycitric acid. Hydroxycitric acid attenuates the oxidative stress induced by calcium oxalate crystallization. Hydroxycitric acid has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Hydroxycitric acid alleviates tubular injury and apoptosis caused by calcium oxalate crystals[1]. The administration of Hydroxycitric acid can suppress body weight gain and fat accumulation in animals[3].
References	[1]. Liu X, et al. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3. [2]. Ibuki M, et al. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20). pii: E5049. [3]. Han S, et al. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667. [4]. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600.

Density	1.98
Boiling Point	309.6ºC at 760 mmHg
Melting Point	275 °C (dec.)(lit.)
Molecular Formula	C₆H₇K₃O₈
Molecular Weight	324.410
Flash Point	155.2ºC
Exact Mass	323.905212
PSA	149.85000
Storage condition	Store at RT.
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	H2O: 1 M at 20 °C, clear, colorless

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T: Toxic;Xi: Irritant;F: Flammable;C: Corrosive;
Risk Phrases	R22
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	1
HS Code	2918150000

HS Code	2918150000
Summary	2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

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