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Related CAS#:
92-43-3 2654-57-1
1158522-08-7 940364-43-2
134104-43-1 131615-57-1
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92-43-3

92-43-3 structure
92-43-3 structure
  • Name: Phenidone
  • Chemical Name: Phenidone
  • CAS Number: 92-43-3
  • Molecular Formula: C9H10N2O
  • Molecular Weight: 162.189
  • Catalog: Chemical reagent Organic reagent Ester Butyl ester compound
  • Create Date: 2018-08-06 10:23:23
  • Modify Date: 2024-01-02 14:26:27
  • Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].
Name Phenidone
Synonyms 1-Phenyl-3-pyrazolidinone
PYRAZOLIDONE A
1-Phenyl-3-oxopyrazolidine
Fenidon
1-phenylpyrazolidin-3-one
1-hydro-2-phenyl-pyrazol-5-one
phenitone
N-phenylpyrazolidin-3-one
1-P-3-P
1H-pyrazol-3-ol, 4,5-dihydro-1-phenyl-
1-Phenyl-3-pyrazolidone
UNII-H0U5612P6K
PHENIDONE A
1-phenyl-1H-pyrazolidin-3-one
2-Pyrazolin-3-ol, 1-phenyl-
3-Pyrazolidinone, 1-phenyl-
MFCD00003094
A PHENIDONE A
B PHENIDONE B
S PHENIDONE S
1-phenyl-pyrazolidin-3-on
EINECS 202-155-1
graphidone
Edaravone Impurity 16
Description Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].
Related Catalog
Target

COX

LOX

In Vitro Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE)[1].
In Vivo Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2].
References

[1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210.

[2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58.

[3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587.

Density 1.2±0.1 g/cm3
Boiling Point 304.1±25.0 °C at 760 mmHg
Melting Point 119-121 °C(lit.)
Molecular Formula C9H10N2O
Molecular Weight 162.189
Flash Point 137.7±23.2 °C
Exact Mass 162.079315
PSA 32.34000
LogP 0.20
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.620
Stability Stable, but light sensitive. Incompatible with strong acids, strong oxidizing agents, strong bases.
Water Solubility SOLUBLE IN HOT WATER

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ8750000
CHEMICAL NAME :
3-Pyrazolidinone, 1-phenyl-
CAS REGISTRY NUMBER :
92-43-3
LAST UPDATED :
199712
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C9-H10-N2-O
MOLECULAR WEIGHT :
162.21
WISWESSER LINE NOTATION :
T5NMVTJ AR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
309 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(1),49,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
287 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1310 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
986 mg/kg/61D-I
TOXIC EFFECTS :
Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0749 No. of Facilities: 1437 (estimated) No. of Industries: 14 No. of Occupations: 7 No. of Employees: 6865 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0749 No. of Facilities: 4414 (estimated) No. of Industries: 34 No. of Occupations: 37 No. of Employees: 51775 (estimated) No. of Female Employees: 25903 (estimated)
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H411
Precautionary Statements P273
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases R22;R51/53
Safety Phrases S61
RIDADR UN 2811 6.1/PG 3
WGK Germany 2
RTECS UQ8750000
Packaging Group III
Hazard Class 6.1
HS Code 2933199090
HS Code 2933199090
Summary 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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