Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 3-Maleimidopropionic acid
Price: ￥1068.0/25g ￥528.0/10g ￥188.0/1g ￥98.0/250mg
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: 3-Maleimidopropionic acid
Price: ￥Inquiry/10g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Lihua Yang

DC Chemicals Limited
China
Product Name: BMPA Protein Modifier
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-Maleimidopropionic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

7423-55-4

7423-55-4 structure

7423-55-4 structure

Name: 3-Maleimidopropionic acid
Chemical Name: 3-Maleimidopropionic Acid
CAS Number: 7423-55-4
Molecular Formula: C₇H₇NO₄
Molecular Weight: 169.135
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-30 16:30:23
Modify Date: 2024-01-02 11:47:04
3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	3-Maleimidopropionic Acid
Synonyms	BMPA β-Maleimidopropionic acid MFCD00043030 3-(2,5-dioxopyrrol-1-yl)propanoic acid 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid 1H-Pyrrole-1-propanoic acid, 2,5-dihydro-2,5-dioxo- 3-Maleimidopropionic acid 3-Maleimidopropionicacid

Description	3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.5±0.1 g/cm3
Boiling Point	382.5±25.0 °C at 760 mmHg
Melting Point	103-106 °C(lit.)
Molecular Formula	C₇H₇NO₄
Molecular Weight	169.135
Flash Point	185.1±23.2 °C
Exact Mass	169.037506
PSA	74.68000
LogP	0.04
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.565
Storage condition	-15°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2925190090

108-31-6 structure

108-31-6

107-95-9 structure

107-95-9

~83%

7423-55-4 structure

7423-55-4

Literature: Han, Jing; Sun, Lidan; Chu, Yingying; Li, Zheng; Huang, Dandan; Zhu, Xiaoyun; Qian, Hai; Huang, Wenlong Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9955 - 9968

57079-11-5 structure

57079-11-5

~12%

7423-55-4 structure

7423-55-4

Literature: Veprek, Pavel; Hajduch, Marian; Dzubak, Petr; Kuklik, Rostislav; Polakova, Jana; Bezouska, Karel Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6400 - 6407

108-31-6 structure

108-31-6

64-19-7 structure

64-19-7

107-95-9 structure

107-95-9

~48%

7423-55-4 structure

7423-55-4

Literature: Yang, Hai-Kuan; Su, Ming-Ming; Ren, Li-Jun; Tang, Jing; Yan, Yu-Kun; Miao, Wen-Ke; Zheng, Ping; Wang, Wei European Journal of Inorganic Chemistry, 2013 , # 8 p. 1381 - 1389

Precursor 4
108-31-6 107-95-9 57079-11-5 64-19-7
DownStream 4
55750-62-4 57-13-6 22011-03-6 121215-45-0

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%