3-Maleimidopropionic acid
3-Maleimidopropionic acid structure
|
Common Name | 3-Maleimidopropionic acid | ||
|---|---|---|---|---|
| CAS Number | 7423-55-4 | Molecular Weight | 169.135 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 382.5±25.0 °C at 760 mmHg | |
| Molecular Formula | C7H7NO4 | Melting Point | 103-106 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 185.1±23.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 3-Maleimidopropionic acid3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 3-Maleimidopropionic Acid |
|---|---|
| Synonym | More Synonyms |
| Description | 3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 382.5±25.0 °C at 760 mmHg |
| Melting Point | 103-106 °C(lit.) |
| Molecular Formula | C7H7NO4 |
| Molecular Weight | 169.135 |
| Flash Point | 185.1±23.2 °C |
| Exact Mass | 169.037506 |
| PSA | 74.68000 |
| LogP | 0.04 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.565 |
| Storage condition | -15°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2925190090 |
|
~83%
3-Maleimidoprop... CAS#:7423-55-4 |
| Literature: Han, Jing; Sun, Lidan; Chu, Yingying; Li, Zheng; Huang, Dandan; Zhu, Xiaoyun; Qian, Hai; Huang, Wenlong Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9955 - 9968 |
|
~12%
3-Maleimidoprop... CAS#:7423-55-4 |
| Literature: Veprek, Pavel; Hajduch, Marian; Dzubak, Petr; Kuklik, Rostislav; Polakova, Jana; Bezouska, Karel Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6400 - 6407 |
|
~48%
3-Maleimidoprop... CAS#:7423-55-4 |
| Literature: Yang, Hai-Kuan; Su, Ming-Ming; Ren, Li-Jun; Tang, Jing; Yan, Yu-Kun; Miao, Wen-Ke; Zheng, Ping; Wang, Wei European Journal of Inorganic Chemistry, 2013 , # 8 p. 1381 - 1389 |
CAS#:55750-62-4
CAS#:57-13-6
CAS#:22011-03-6
CAS#:121215-45-0| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
|
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Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a.
J. Biol. Chem. 290 , 17956-66, (2015) Acid-sensing ion channels (ASICs) are neuronal, voltage-independent Na(+) channels that are transiently activated by extracellular acidification. They are involved in pain sensation, the expression of... |
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Selective and Sensitive Sensing of Flame Retardant Chemicals Through Phage Display Discovered Recognition Peptide.
Nano Lett. 15 , 7697-703, (2015) We report a highly selective and sensitive biosensor for the detection of an environmentally toxic molecule, decabrominated diphenyl ether (DBDE), one of the most common congeners of the polybrominate... |
| BMPA |
| β-Maleimidopropionic acid |
| MFCD00043030 |
| 3-(2,5-dioxopyrrol-1-yl)propanoic acid |
| 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid |
| 1H-Pyrrole-1-propanoic acid, 2,5-dihydro-2,5-dioxo- |
| 3-Maleimidopropionic acid |
| 3-Maleimidopropionicacid |
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