Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-
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80-75-1

80-75-1 structure

Name: Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)
Chemical Name: 11α-hydroxyprogesterone
CAS Number: 80-75-1
Molecular Formula: C₂₁H₃₀O₃
Molecular Weight: 330.46
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-06-25 18:40:27
Modify Date: 2026-07-26 22:33:31
11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.

Name	11α-hydroxyprogesterone
Synonyms	11-Hydroxypregn-4-ene-3,20-dione DG 322B Progesterone, 11alpha-hydroxy Pregn-4-ene-3,20-dione, 11-hydroxy-, (11α) 11A-HYDROXY-4-PREGNENE-3,20-DIONE Progesterone,11alpha-hydroxy (8S,9S,10R,11R,13S,14S,17S)-17-ACETYL-11-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE 11ALPHA-HYDROXYPROGESTERONE Pregn-4-en-11α-ol-3,20-dione U 0384 11α-Hydroxy-4-pregnene-3,20-dione, 4-Pregnen-11α-ol-3,20-dione 11-alpha-Hydroxyprogesterone11alpha-Hydroxy-4-pregnene-3,20-dione HYDROXYPROGESTERONE, 11A Pregn-4-ene-3,20-dione, 11alpha-hydroxy DELTA4-PREGNEN-11ALPHA-OL-3,20-DIONE 4-Pregnene-11α-ol-3,20-dione EINECS 201-306-9 MFCD00003652 11-alpha-Hydroxyprogesterone 11A-HYDROXYPREGN-4-ENE-3,20-DIONE 11α-Hydroxy-4-pregnene-3,20-dione(4-Pregnen-11α-ol-3,20-dione) 11alpha-hydroxyprogesterone HYDROXYPROGESTERONE,11A 11-alfa-Hydroxy Progesterone 11α-Hydroxypregn-4-ene-3,20-dione, 4-Pregnen-11α-ol-3,20-dione Progesterone 11alpha-Hydroxy Impurity 4-PREGNEN-11A-OL-3,20-DIONE 11ALPHA-HYDROXY-4-PREGNENE-3,20-DIONE 4-PREGNEN-11α-OL-3, 20-DIONE 4-Pregnen-Α11-Ol-3, 20-Dione Pregn-4-ene-3,20-dione,11-hydroxy-, (11a) (11α)-11-Hydroxypregn-4-ene-3,20-dione 11α-Hydroxy-4-pregnene-3,20-dione 11A-HYDROXYPROGESTERONE 11α-Hydroxy Progesterone/11-alfa-Hydroxy Progesterone/(11α)-11-Hydroxypregn-4-ene-3,20-dione 11ALPHA-HYDROXYPREGN-4-ENE-3,20-DIONE 4-PREGNEN-11ALPHA-OL-3,20-DIONE (8S,9S,10R,11R,13S,14S,17S)-17-acetyl-11-hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one 11α-Hydroxy Progesterone

Description	11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13. [2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5.

Density	1.15 g/cm3
Boiling Point	487.4ºC at 760 mmHg
Melting Point	165-166ºC(lit.)
Molecular Formula	C₂₁H₃₀O₃
Molecular Weight	330.46
Flash Point	262.7ºC
Exact Mass	330.21900
PSA	54.37000
LogP	3.69430
Index of Refraction	1.557
Storage condition	Refrigerator

Safety Phrases	S24/25
WGK Germany	3
RTECS	TU5057000

Precursor 6
145-13-1 2268-98-6 13656-06-9 600-48-6
57-83-0 50909-92-7
DownStream 10
516-15-4 21063-87-6 57-83-0 128-23-4
128-20-1 3066-12-4 640-33-5 2268-98-6
2625-60-7 17652-16-3

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