80-75-1

80-75-1 structure

Name: Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-
Chemical Name: 11α-hydroxyprogesterone
CAS Number: 80-75-1
Molecular Formula: C₂₁H₃₀O₃
Molecular Weight: 330.46
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-06-25 18:40:27
Modify Date: 2024-01-02 13:41:13
11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.

Name	11α-hydroxyprogesterone
Synonyms	11alpha-hydroxyprogesterone HYDROXYPROGESTERONE,11A DG 322B 11A-HYDROXYPROGESTERONE EINECS 201-306-9 4-PREGNEN-11A-OL-3,20-DIONE MFCD00003652 Progesterone,11alpha-hydroxy Progesterone, 11.α.-hydroxy- U 0384

Description	11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13. [2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5.