Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)
Modify Date: 2025-08-25 21:26:23
Pregn-4-ene-3,20-dione,11-hydroxy-, (11α) structure
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Common Name | Pregn-4-ene-3,20-dione,11-hydroxy-, (11α) | ||
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| CAS Number | 80-75-1 | Molecular Weight | 330.46 | |
| Density | 1.15 g/cm3 | Boiling Point | 487.4ºC at 760 mmHg | |
| Molecular Formula | C21H30O3 | Melting Point | 165-166ºC(lit.) | |
| MSDS | N/A | Flash Point | 262.7ºC | |
Use of Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. |
| Name | 11α-hydroxyprogesterone |
|---|---|
| Synonym | More Synonyms |
| Description | 11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. |
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| Related Catalog | |
| References |
| Density | 1.15 g/cm3 |
|---|---|
| Boiling Point | 487.4ºC at 760 mmHg |
| Melting Point | 165-166ºC(lit.) |
| Molecular Formula | C21H30O3 |
| Molecular Weight | 330.46 |
| Flash Point | 262.7ºC |
| Exact Mass | 330.21900 |
| PSA | 54.37000 |
| LogP | 3.69430 |
| Index of Refraction | 1.557 |
| InChIKey | BFZHCUBIASXHPK-QJSKAATBSA-N |
| SMILES | CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C |
| Storage condition | Refrigerator |
| Safety Phrases | S24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS | TU5057000 |
| Precursor 6 | |
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| DownStream 10 | |
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: In vitro antagonist activity against rat prostatic androgen receptor (AR)
Source: ChEMBL
Target: Androgen receptor
External Id: CHEMBL652259
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Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation...
Source: NMMLSC
Target: ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens]
External Id: UNMCMD_ABCB6_1o_ValidationSet
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| 11alpha-hydroxyprogesterone |
| HYDROXYPROGESTERONE,11A |
| DG 322B |
| 11A-HYDROXYPROGESTERONE |
| EINECS 201-306-9 |
| 4-PREGNEN-11A-OL-3,20-DIONE |
| MFCD00003652 |
| Progesterone,11alpha-hydroxy |
| U 0384 |