Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)
Pregn-4-ene-3,20-dione,11-hydroxy-, (11α) structure
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Common Name | Pregn-4-ene-3,20-dione,11-hydroxy-, (11α) | ||
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| CAS Number | 80-75-1 | Molecular Weight | 330.46 | |
| Density | 1.15 g/cm3 | Boiling Point | 487.4ºC at 760 mmHg | |
| Molecular Formula | C21H30O3 | Melting Point | 165-166ºC(lit.) | |
| MSDS | N/A | Flash Point | 262.7ºC | |
Use of Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 11α-hydroxyprogesterone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.15 g/cm3 |
|---|---|
| Boiling Point | 487.4ºC at 760 mmHg |
| Melting Point | 165-166ºC(lit.) |
| Molecular Formula | C21H30O3 |
| Molecular Weight | 330.46 |
| Flash Point | 262.7ºC |
| Exact Mass | 330.21900 |
| PSA | 54.37000 |
| LogP | 3.69430 |
| Index of Refraction | 1.557 |
| InChIKey | BFZHCUBIASXHPK-QJSKAATBSA-N |
| SMILES | CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C |
| Storage condition | Refrigerator |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Safety Phrases | S24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS | TU5057000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 6 | |
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| DownStream 10 | |
CAS#:145-13-1
CAS#:2268-98-6
CAS#:13656-06-9![(6R,8S,9S,10R,11R,13R,14S,17S)-17-acetyl-6,11-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Structure](https://image.chemsrc.com/caspic/396/600-48-6.png)
CAS#:600-48-6
CAS#:57-83-0
CAS#:50909-92-7
CAS#:516-15-4
CAS#:21063-87-6
CAS#:128-23-4
CAS#:128-20-1
CAS#:3066-12-4
CAS#:640-33-5
CAS#:2625-60-7
CAS#:17652-16-3This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: In vitro antagonist activity against rat prostatic androgen receptor (AR)
Source: ChEMBL
Target: Androgen receptor
External Id: CHEMBL652259
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Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation...
Source: NMMLSC
Target: ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens]
External Id: UNMCMD_ABCB6_1o_ValidationSet
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 11alpha-hydroxyprogesterone |
| HYDROXYPROGESTERONE,11A |
| DG 322B |
| 11A-HYDROXYPROGESTERONE |
| EINECS 201-306-9 |
| 4-PREGNEN-11A-OL-3,20-DIONE |
| MFCD00003652 |
| Progesterone,11alpha-hydroxy |
| U 0384 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of 11α-hydroxyprogesterone? |
| A: SMILES notation of 11α-hydroxyprogesterone is CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C. |
| Q: What is the polar surface area (PSA) of 11α-hydroxyprogesterone? |
| A: Polar surface area (PSA) of 11α-hydroxyprogesterone is 54.37000. |
| Q: What is the LogP of 11α-hydroxyprogesterone? |
| A: LogP of 11α-hydroxyprogesterone is 3.69430. |
| Q: What is the boiling point of 11α-hydroxyprogesterone? |
| A: Boiling point of 11α-hydroxyprogesterone is 487.4ºC at 760 mmHg. |
| Q: What is the InChIKey of 11α-hydroxyprogesterone? |
| A: InChIKey of 11α-hydroxyprogesterone is BFZHCUBIASXHPK-QJSKAATBSA-N. |
| Q: What is the CAS number of 11α-hydroxyprogesterone? |
| A: CAS number of 11α-hydroxyprogesterone is 80-75-1. |
| Q: What is the English name of 11α-hydroxyprogesterone? |
| A: The English name of 11α-hydroxyprogesterone is 11α-hydroxyprogesterone. |
| Q: What are the downstream products of 11α-hydroxyprogesterone? |
| A: Related downstream products(CAS) of 11α-hydroxyprogesterone: 516-15-4;21063-87-6;57-83-0;128-23-4;128-20-1;3066-12-4;640-33-5;2268-98-6;2625-60-7;17652-16-3. |
| Q: What is the molecular formula of 11α-hydroxyprogesterone? |
| A: Molecular formula of 11α-hydroxyprogesterone is C21H30O3. |
| Q: What are the upstream materials of 11α-hydroxyprogesterone? |
| A: Related upstream materials(CAS) of 11α-hydroxyprogesterone: 145-13-1;2268-98-6;13656-06-9;600-48-6;57-83-0;50909-92-7. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |