Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-

Modify Date: 2024-01-02 13:41:13

Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)- structure	Common Name	Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-
	CAS Number	80-75-1	Molecular Weight	330.46
	Density	1.15 g/cm3	Boiling Point	487.4ºC at 760 mmHg
	Molecular Formula	C₂₁H₃₀O₃	Melting Point	165-166ºC(lit.)
	MSDS	N/A	Flash Point	262.7ºC

Use of Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-

11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.

Name	11α-hydroxyprogesterone
Synonym	More Synonyms

Description	11alpha-Hydroxyprogesterone is the inactive analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13. [2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

References

[1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13.

[2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5.

Density	1.15 g/cm3
Boiling Point	487.4ºC at 760 mmHg
Melting Point	165-166ºC(lit.)
Molecular Formula	C₂₁H₃₀O₃
Molecular Weight	330.46
Flash Point	262.7ºC
Exact Mass	330.21900
PSA	54.37000
LogP	3.69430
Index of Refraction	1.557
Storage condition	Refrigerator

MSDS(Chinese)

Safety Phrases	S24/25
WGK Germany	3
RTECS	TU5057000

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