70-07-5

• 常用中文名：美芬诺酮
• 常用英文名：mephenoxalone
• CAS号：70-07-5
• 分子式：C₁₁H₁₃NO₄
• 分子量：223.23
• 相关类别： 信号通路 细胞凋亡 Bcl-2家族
• 发布时间：2018-08-25 11:59:21
• 更新时间：2024-01-02 17:29:44
• Mephenoxalone 抑制神经元传递,通过抑制反射弧使骨骼肌放松。

名称

• 中文名: 美芬诺酮
• 英文名: 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one
• 中文别名: 5-[(2-甲氧基苯氧基)甲基]-2-恶唑烷酮
• 英文别名: Control-OM; 5-[(2-Methoxyphenoxy)methyl]-1,3-oxazolidin-2-one; 2-Oxazolidinone, 5-[(2-methoxyphenoxy)methyl]-; Mefenoxalona; Mefenoxalone; EINECS 200-723-3; mephenoxalone; 5-({[2-(methyloxy)phenyl]oxy}methyl)-1,3-oxazolidin-2-one; Moderamin; Methoxydone; 5-[(2-Methoxyphenoxy)methyl]-2-oxazolidinone; Methoxydon; Dorsiflex

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 440.0±18.0 °C at 760 mmHg
• 分子式: C₁₁H₁₃NO₄
• 分子量: 223.23
• 闪点: 219.9±21.2 °C
• 精确质量: 223.084457
• PSA: 56.79000
• LogP: 1.32
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.521
• 分子结构:

  1、 摩尔折射率：71.47

  2、 摩尔体积（cm³/mol）：202.7

  3、 等张比容（90.2K）：648.4

  4、 表面张力（dyne/cm）：104.5

  5、 极化率（10-24cm3）：28.33

生物活性

• 描述: Mephenoxalone 抑制神经元传递,通过抑制反射弧使骨骼肌放松。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. K F BENITZ, et al. Toxicity studies on mephenoxalone in rats and dogs. Toxicol Appl Pharmacol (IF: 4.22; Q2). 1962 Mar;4:220-37.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RQ3500000 CHEMICAL NAME : 2-Oxazolidinone, 5-((o-methoxyphenoxy)methyl)- CAS REGISTRY NUMBER : 70-07-5 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C11-H13-N-O4 MOLECULAR WEIGHT : 223.25 WISWESSER LINE NOTATION : T5MVOTJ D1OR BO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3820 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,642,1964 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,198,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 11,212,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires, Argentina) V.1-89, 1915-76. Discontinued. Volume(issue)/page/year: 74,82,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30330 mg/kg/30D-C TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in ovarian weight REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 18 gm/kg/30D-I TOXIC EFFECTS : Behavioral - food intake (animal) Liver - other changes Blood - normocytic anemia REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 87 gm/kg/26W-I TOXIC EFFECTS : Behavioral - ataxia Blood - normocytic anemia REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

安全

• 海关编码: 2934999090

合成路线

60420-27-1 870-63-3 ~10% 70-07-5

文献：Smith III, Amos B.; Hirschmann, Ralph F.; Nittoli, Thomas; Sprengeler, Paul Patent: US2002/123635 A1, 2002 ;

124-38-9 943962-56-9 ~90% 70-07-5

文献：Madhusudhan; Reddy, M. Srinivasa; Reddy, Y. Narayana; Vijayalakshmi; Suribabu; Balraju Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 7 p. 978 - 984

590-28-3 25772-81-0 ~66% 70-07-5

文献：Chinnam Naidu; Ravi Babu; Gangaiah; Mukkanti; Madhusudhan Tetrahedron Letters, 2010 , vol. 51, # 8 p. 1226 - 1229

93-14-1 57-13-6 ~% 70-07-5

文献：Lunsford,C.D. et al. Journal of the American Chemical Society, 1960 , vol. 82, p. 1166 - 1171

153756-96-8 ~% 103-90-2 70-07-5

文献：Vigroux, Alain; Bergon, Michel; Zedde, Chantal Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 3983 - 3994

上下游产品

上游产品  7
60420-27-1 870-63-3 124-38-9 590-28-3
93-14-1 57-13-6 153756-96-8
下游产品  3
366789-02-8 77943-39-6 104-21-2

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%