18490-95-4

18490-95-4 structure

Name: Brevifolincarboxylic acid
Chemical Name: brevifolin carboxylic acid
CAS Number: 18490-95-4
Molecular Formula: C₁₃H₈O₈
Molecular Weight: 292.198
Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
Create Date: 2018-03-11 08:00:00
Modify Date: 2024-01-02 10:20:49
Brevifolincarboxylic acid is extracted from Polygonum capitatum[1], has inhibitory effect on the aryl hydrocarbon receptor (AhR)[2]. Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM[3].

Name	brevifolin carboxylic acid
Synonyms	Benzo[d]cyclopenta[b]pyran-1-carboxylic acid, 1,2,3,5-tetrahydro-7,8,9-trihydroxy-3,5-dioxo- brevifolincarboxylic acid 7,8,9-Trihydroxy-3,5-dioxo-1,2,3,5-tetrahydrocyclopenta[c]isochromene-1-carboxylic acid

Description	Brevifolincarboxylic acid is extracted from Polygonum capitatum[1], has inhibitory effect on the aryl hydrocarbon receptor (AhR)[2]. Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM[3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	IC50: 323.46 μM (α-glucosidase) (Brevifolincarboxylic acid)[3]
References	[1]. Chen X, et al. Simultaneous isolation and purification of gallic acid and brevifolincarboxylic acid from Polygonum capitatum by high-speed counter-current chromatography. Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(15):1957-60. [2]. Amakura Y, et al. Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Pharm Bull. 2003 Dec; 26(12):1754-60. [3]. Liu M, et al. Separation of α-glucosidase inhibitors from Potentilla kleiniana Wight et Arn using solvent and flow-rate gradient high-speed counter-current chromatography target-guided by ultrafiltration HPLC-MS screening. Phytochem Anal. 2019 May 6.