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499-75-2

499-75-2 structure
499-75-2 structure
Name carvacrol
Synonyms 2-hydroxy-4-(2-propyl)toluene
ISOTHYMOL
o-Cresol, 5-isopropyl
CVACROL(P)
P-CYMEN-2-OL
3-Isopropyl-6-methylphenol
CVACROL
2-methyl-5-(1-methylethyl)-pheno
2-METHYL-5-(1-METHYLETHYL)PHENOL
2-methyl-5-(1-methylethyl)phenol
2-HYDROXY-4-ISOPROPYL-1-METHYLBENZENE
CVACROL, NATURAL
Methyl-5-(1-methylethyl)phenol
2-METHYL-5-ISOPROPYLPHENOL
2-p-Cymenol
2-pa-cymenol
5-ISOPROPYL-2-METHYLPHENOL
EINECS 207-889-6
2-HYDROXY-P-CYMENE
2-HYDROXY-4-CYMENE
2-methyl-5-propan-2-ylphenol
1-Hydroxy-2-methyl-5-isopropylbenzene
Isothymol 5-Isopropyl-o-cresol 5-Isopropyl-2-methylphenol
CYMOPHENOL
Cymenol
5-Isopropyl-2-Methylphenol
MFCD00002236
CVACROL(SG)
THYMOL, ISO
2-Hydroxy-1-methyl-4-(1-methylethyl)benzene
6-methyl-3-isopropylphenol
2-Cymophenol
Isopropyl-o-cresol
CVACROL WITH
o-Thymol
Hydroxy-p-cymene
2-hydroxy-p-cymen
Oxycymol
5-isopropyl-o-creso
p-Cymene, 2-hydroxy
Isopropylo-cresol
CVEOL, (-)-(RG)
5-isopropyl-2-methyl-pheno
Cvacrol,5-Isopropyl-2-Methylphenol
Phenol,2-methyl-5-(1-methylethyl)
3-isopropyl-6-methyl-pheno
Antioxine
5-Isopropyl-o-cresol
2-HydroxycyMene
Kvakrol
CVACROL FCC
o-cresol,5-isopropyl
Isopropylhydroxytoluene
Phenol, 3-isopropyl-6-methyl
5-ISOPROPYL-O-CRESOL
Phenol, 5-isopropyl-2-methyl
Description Carvacrol is a monoterpenoid phenol isolated from Lamiaceae family plants, with antioxidant, anti-inflammatory and anticancer properties. Carvacrol causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis[1].
Related Catalog
References

[1]. Khan F, et al. Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. Anticancer Agents Med Chem. 2019 Jul 31.
Density 1.0±0.1 g/cm3
Boiling Point 237.2±9.0 °C at 760 mmHg
Melting Point 3-4 °C(lit.)
Molecular Formula C10H14O
Molecular Weight 150.218
Flash Point 106.7±0.0 °C
Exact Mass 150.104462
PSA 20.23000
LogP 3.28
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.523
Stability Stable. Combustible. Incompatible with strong bases, strong oxidizing agents.
Water Solubility Insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FI1225000
CHEMICAL NAME :
Carvacrol
CAS REGISTRY NUMBER :
499-75-2
BEILSTEIN REFERENCE NO. :
1860514
LAST UPDATED :
199701
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C10-H14-O
MOLECULAR WEIGHT :
150.24
WISWESSER LINE NOTATION :
QR B1 EY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,743,1979 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
810 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
73300 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands) V.1-19, 1961-81. For publisher information, see IJCREE. Volume(issue)/page/year: 19,1,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
680 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952- Volume(issue)/page/year: 3,73,1952
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
310 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 3,109,1948
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,46,1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 161,196,1931
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,366,1949
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,46,1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,46,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5071 No. of Facilities: 1235 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees: 7449 (estimated) No. of Female Employees: 979 (estimated)
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive
Risk Phrases R22;R34
Safety Phrases S26-S36/37/39-S45
RIDADR UN 3265 8/PG 3
WGK Germany 3
RTECS FI1225000
Packaging Group III
Hazard Class 8
HS Code 2907199090
HS Code 2907199090
Summary 2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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