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115-20-8

115-20-8 structure
115-20-8 structure
  • Name: Ethapon
  • Chemical Name: 2,2,2-trichloroethanol
  • CAS Number: 115-20-8
  • Molecular Formula: C2H3Cl3O
  • Molecular Weight: 149.404
  • Catalog: Chemical reagent Organic reagent Fatty alcohol
  • Create Date: 2018-04-21 08:00:00
  • Modify Date: 2026-07-03 18:12:27
  • 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].
Name 2,2,2-trichloroethanol
Synonyms 2,2,2-Trichloroethyl alcohol
2,2,2-Trichloroethanol
beta,beta,.beta-Trichloroethanol
2,2,2-Trichloroethanol Vetec(TM) ade
2-Hydroxy-1,1,1-trichloroethane
2,2,2-Trichloroethanol, 10 mM in DMSO
2,2,2-TRICHLORETHANOL
Trichloroethanol
2.2.2-Trichlor
2,2,2-TrichL
2,2,2-TRICHLOROETHANOL OEKANAL
beta,beta,beta-trichloroethanol
(Hydroxymethyl)trichloromethane
2,2,2-Trichloroethanol, R
1-Hydroxy-2,2,2-trichloroethane
Trichlorethanol
TRICHLOROETHYL ALCOHOL
BETA,BETA,BETA-TRICHLOROETHYL ALCOHOL
2,2,2-Trichloroethanol ReagentPlus(R), >=
2,2,2-Trichloroethan-1-ol
trichloroethanol
2,2,2-Trichloroethanol >
2,2,2-trichloro-ethano
CCl3CH2OH
2,2,2-Trichloro-1-ethanol
Acetone ethanol
oroethanoL
Trichloroethyl alcohol
EINECS 204-071-0
MFCD00004677
Ethanol, 2,2,2-trichloro
2,2,2-trichloroethylalcohol
2,2,2-TRICHLOROETHANOL
Description 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].
Related Catalog
In Vitro 2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery[1].
References

[1]. Nikhil K Parelkar , et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.
Density 1.6±0.1 g/cm3
Boiling Point 152.1±35.0 °C at 760 mmHg
Melting Point 17.8 °C(lit.)
Molecular Formula C2H3Cl3O
Molecular Weight 149.404
Flash Point 45.8±25.9 °C
Exact Mass 147.924942
PSA 20.23000
LogP 1.38
Vapour density 5.16 (vs air)
Vapour Pressure 1.3±0.6 mmHg at 25°C
Index of Refraction 1.499

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM3850000
CHEMICAL NAME :
Ethanol, 2,2,2-trichloro-
CAS REGISTRY NUMBER :
115-20-8
BEILSTEIN REFERENCE NO. :
1697495
LAST UPDATED :
199710
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C2-H3-Cl3-O
MOLECULAR WEIGHT :
149.40
WISWESSER LINE NOTATION :
Q1XGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Rectal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4200 mg/kg/14D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in calcium
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14400 mg/kg/90D-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in calcium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
178 gm/L
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 3,63,1981
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H318-H336
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful;
Risk Phrases R22;R41
Safety Phrases S26-S39
RIDADR 1760
WGK Germany 1
RTECS KM3850000
Packaging Group III
HS Code 29055910
HS Code 2905590090
Summary 2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
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