Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ethapon
Price:
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ethapon
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: 2,2,2-Trichloroethanol
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,2,2-Trichloroethanol
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Trichloroethanol 99.0%
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Purity: 99.0%
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115-20-8

115-20-8 structure

115-20-8 structure

Name: Ethapon
Chemical Name: 2,2,2-trichloroethanol
CAS Number: 115-20-8
Molecular Formula: C₂H₃Cl₃O
Molecular Weight: 149.404
Catalog: Chemical reagent Organic reagent Fatty alcohol
Create Date: 2018-04-21 08:00:00
Modify Date: 2024-01-04 18:25:01
2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].

Name	2,2,2-trichloroethanol
Synonyms	Ethanol, 2,2,2-trichloro- 2,2,2-Trichloroethanol Trichloroethyl alcohol EINECS 204-071-0 MFCD00004677 Trichloroethanol Ethapon

Description	2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery[1].
References	[1]. Nikhil K Parelkar , et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.

Density	1.6±0.1 g/cm3
Boiling Point	152.1±35.0 °C at 760 mmHg
Melting Point	17.8 °C(lit.)
Molecular Formula	C₂H₃Cl₃O
Molecular Weight	149.404
Flash Point	45.8±25.9 °C
Exact Mass	147.924942
PSA	20.23000
LogP	1.38
Vapour density	5.16 (vs air)
Vapour Pressure	1.3±0.6 mmHg at 25°C
Index of Refraction	1.499

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM3850000

CHEMICAL NAME :: Ethanol, 2,2,2-trichloro-

CAS REGISTRY NUMBER :: 115-20-8

BEILSTEIN REFERENCE NO. :: 1697495

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C2-H3-Cl3-O

MOLECULAR WEIGHT :: 149.40

WISWESSER LINE NOTATION :: Q1XGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - sleep

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4200 mg/kg/14D-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in calcium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14400 mg/kg/90D-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in calcium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 178 gm/L

REFERENCE :: TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 3,63,1981

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318-H336
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R41
Safety Phrases	S26-S39
RIDADR	1760
WGK Germany	1
RTECS	KM3850000
Packaging Group	III
HS Code	29055910

Precursor 10
515-84-4 302-17-0 75-87-6 41262-38-8
86379-25-1 76-02-8 76-03-9 50-00-0
67-66-3 108-93-0
DownStream 10
1118-44-1 107-69-7 451-40-1 101-81-5
632-50-8 143330-91-0 44925-09-9 20405-30-5
82564-87-2 123-54-6

HS Code	2905590090
Summary	2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%