| Name | stigmasterol |
|---|---|
| Synonyms |
(24S)-5,22-Stigmastadien-3b-ol
Stigmasta-5,22-dien-3b-ol STIGMASTA-5,22-DIEN-3BETA-OL STIGMASTEROL (STIGMASTERIN) beta-Stigmasterol (24S)-Stigmast-5,22-dien-3β-ol 2-(4-Chlorophenyl)sulfanylethanol Stigmasta-5,22-dien-3-ol, (3beta,22E) 5,22-CHOLESTADIEN-24B-ETHYL-3BETA-OL StigMasterol, R Stigmasta-5,22-dien-3-ol, (3β,22E) Wulzen anti-stiffness factor Stigmasta-5,22-dien-3-ol, (3β,22E)- (9CI) 5,22-Cholestadien-24-ethyl-3beta-ol Serposterol Stigmasterol > δ5,22-Stigmastadien-3β-ol Anti-stiffness factor (3β,22E)-Stigmasta-5,22-dien-3-ol Stigmasta-5,22-dien-3β-ol (8CI) Stigmastero 24-Ethylcholesta-5,22-dien-3beta-ol (22E)-Stigmasta-5,22-dien-3-ol 5,22-STIGMASTADIEN-3-BETA-OL 5,22-StigMastadiene-3β-ol 24β-Ethyl-5,22-cholestadien-3β-ol 24-Ethyl-5,22-cholestadien-3β-ol Stigmasta-5,22-dien-3-ol, (3b,22E) Stigmasterin (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-Ethyl-6-methyl-3-hepten-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (3β,20R,22E,24S)-Stigmasta-5,22-dien-3-ol δ5-Stigmasterol (24S)-24-Ethylcholesta-5,22-dien-3b-ol stigmasta-5,22-dien-3-β-ol β-Stigmasterol DELTA5,22-Stigmastadien-3beta-ol STIGMASTEROL extrapure Stigmasterol //BP (5R,8R,9S,10S,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylht-3-en-2-yl]-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one (3b,22E)-Stigmasta-5,22-dien-3-ol 5,22-stigmastadien-3β-ol (3β,22E)-StigMasta-5,22-dien-3-ol I-Stigmasterol 5,22-CHOLESTADIEN-24BETA-ETHYL-3BETA-OL 17-(5-ethyl-6-methyl-ht-3-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 3β-Hydroxy-24-ethyl-5,22-cholestadiene 5,22-Stigmastadien-3β-ol Stigmasta-5,22-dien-3beta-ol Reduce Cholesterol Soybean Extract Phytosterol powder 3β-Hydroxy-24-ethyl-5,22-cholestadiene, 5,22-Stigmastadien-3β-ol, Stigmasterin UNII-99WUK5D0Y8 (3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylht-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 3BETA-HYDROXY-24-ETHYL-5,22-CHOLESTADIENE Stigmasterol,3β-Hydroxy-24-ethyl-5,22-cholestadiene, 5,22-Stigmastadien-3β-ol, Stigmasterin STIGMASTEROL(P) 5,22-Stigmastadien-3β-ol (24S)-24-Ethyl-22,23-didehydrocholesterol Stigmasterol Stigmasta-5,22-dien-3beta-ol Guinea-pig-anti-stiffness factor SULFISOXAZOLE Stigmasta-5,22-dien-3β-ol 22-Dehydro-24-ethylcholesterol Stigmasta-5,22-dien-3-ol MFCD00003630 Stigmasta-5,22E-dien-3β-ol isofucosterol STIGMASTEROL stigmasta-5,22-dien-3-b-ol (22E,24S)-Stigmasta-5,22-diene-3β-ol (22E,24S)-24-Ethylcholesta-5,22-dien-3β-ol STIGMASTERIN EINECS 201-482-7 [3B-HYDROXY-24-ETHYL-D] ZZ-CHOLESTADIENE STIGMASTA-5,22-DIEN-3-OL, (3BETA) 3β-Hydroxy-24-ethyl-5,22-cholestadiene 3b-Hydroxy-24-ethyl-D5,22-cholestadiene 24S-ethylcholest-5,22-dien-3β-ol (24S)-5,22-STIGMASTADIEN-3BETA-OL masteroL (24S)-5,22-Stigmastadien-3β-ol StigMasterol (StigMasterin) Stig PHYTOSTEROL (24S)-24-Ethylcholesta-5,22-dien-3β-ol |
| Description | Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. |
|---|---|
| Related Catalog | |
| Target |
MMP[1] |
| In Vitro | Preincubation of Stigmasterol to IL-1beta-treated cells shows significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE2 protein in human and mouse. Stigmasterol is also capable of counteracting the IL-1beta-induced NF-κB pathway[1]. |
| Cell Assay | A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 501.1±19.0 °C at 760 mmHg |
| Melting Point | 165-167 °C(lit.) |
| Molecular Formula | C29H48O |
| Molecular Weight | 412.691 |
| Flash Point | 219.4±13.7 °C |
| Exact Mass | 412.370514 |
| PSA | 20.23000 |
| LogP | 10.21 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Storage condition | 2~8°C |
| Water Solubility | insoluble |
| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H319-H331-H336-H351-H361d-H372 |
| Precautionary Statements | P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn,Xi |
| Risk Phrases | R22 |
| Safety Phrases | S22-S24/25-S36/37 |
| RIDADR | UN 1888 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 2906199090 |
| Precursor 6 | |
|---|---|
| DownStream 10 | |
| HS Code | 2906199090 |
|---|---|
| Summary | 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |