Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Beta-Sitosterol
  • Price: ￥Inquiry/5mg
  • Purity: 97.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng
Related CAS#:
64997-52-0 83-46-5
3712-16-1 24815-93-8
915-05-9 72884-27-6
4281-99-6 69266-16-6
109119-65-5 3258-02-4
1158522-08-7 940364-43-2
134104-43-1 131615-57-1
6906-52-1 930439-75-1
1018584-77-4 1375289-11-4
849349-65-1 1070882-68-6

83-46-5

83-46-5 structure
83-46-5 structure
Name sitosterol
Synonyms Prostasal
Stigmast-5-en-3-ol, (3β)-
L E5 B666 LUTJ A1 E1 FY1&2Y2&Y1&1 OQ &&Stereoisomer
Sitosterol β
B-Sitosterol
22:23-Dihydrostigmasterol
24b-Ethyl-D5-cholesten-3b-ol
Sitosterol
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-éthyl-6-méthyl-2-heptanyl]-10,13-diméthyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-3-ol
Stigmast-5-en-3-ol, (3β,20R,24R)-
(3β)-Stigmast-5-en-3-ol
Stigmast-5-en-3b-ol
(3b)-Stigmast-5-en-3-ol
α-Phytosterol
MFCD00003631
(3β,20R,24R)-Stigmast-5-en-3-ol
β-Sitosterol
EINECS 201-480-6
Sitosterin
a-Phytosterol
D5-Stigmasten-3b-ol
δ5-Stigmasten-3b-ol
b-Sitosterin
(24R)-Stigmast-5-en-3b-ol
a-Dihydrofucosterol
beta-Sitosterol
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-Ethyl-6-methyl-2-heptanyl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
α-Dihydrofucosterol
Description Beta-Sitosterol weakly inhibits porcine pancreatic lipase (PPL) activity. Sitosterol is an important compound extracted from the leaves of Aloe vera.
Related Catalog
Target

IC50: 99.99±1.86 μg/mL (PPL)[1]

In Vitro Bioactivity-guided isolation afforded three compounds from the hexane fraction of E. indica, namely, Beta-Sitosterol (β-sitosterol), Stigmasterol, and Lutein. Both compounds are found to possess very low PPL inhibition activity, that is, 2.99±0.80% (Beta-Sitosterol) of inhibition at 100 μg/mL (242 μM) and 2.68±0.38% (Stigmasterol) of inhibition at 100 μg/mL (243 μM), respectively. Weak PPL inhibition activity of Beta-Sitosterol and Stigmasterol isolated from Alpinia zerumbet with IC50 value of 99.99±1.86 μg/mL and 125.05±4.76 μg/mL, respectively, in comparison with the inhibition shown by Curcumin (IC50=4.92±0.21 μg/mL) and Quercetin (IC50=18.60±0.86 μg/mL) which are used as positive controls in their study. Beta-Sitosterol and Stigmasterol are recorded with weak PPL inhibitory activity of only 3.0±0.8% and 2.7±0.4% at 100 μg/mL, respectively, (i.e., 242 μM and 243 μM) in contrast (34.5±5.4% at 100 μg/mL), which are comparatively lower than that recorded in literature (i.e., 50% PPL inhibition at 100 μg/mL)[1]. Sitosterol is an important compound extracted from the leaves of Aloe vera. It inhibits the growth of promastigotes of L. donovani, a causative agent for life threatening visceral leishmaniasis disease[2].
In Vivo Beta-Sitosterol (β-sitosterol) treatment significantly reduced the immobility time at three doses (10, 20, and 30 mg/kg) in the Forced Swim Test (FST) and Tail Suspension Test (TST), indicating an antidepressant effect. This effect is similar to the positive control fluoxetine (20 mg/kg) at a dose of 30 mg/kg, where the strongest effect is observed compared with the control group (P < 0.001). The same effects are observed for three doses of Beta-Sitosterol in the TST. The % DID values are as follows: FST: 39.27% (10 mg/kg), 51.23% (20 mg/kg), and 57.48% (30 mg/kg); TST: 31.63% (10 mg/kg), 43.95% (20 mg/kg), and 53.38% (30 mg/kg). These results indicate that Beta-Sitosterol has a significant antidepressant activity in mice during the FST and TST. Furthermore, Beta-Sitosterol exhibits the antidepressant effect in a dose-dependent manner[3].
Animal Admin Mice[3] Male ICR mice (20±2 g) and male KunMing mice (20±2 g) are used. Local breed, male ICR mice (20±2 g) are used in the FST under standard conditions with free access to food and water. Mice are randomly divided into four groups (8 mice per group are used) for the tail suspension test (TST): Beta-Sitosterol (10, 20, and 30 mg/kg), total sterols (50, 100, and 200 mg/kg), fluoxetine (20 mg/kg), or distilled water. 80 male mice are used. Briefly, the vehicle or test drugs are administered 30 min before a test session acute ip injection. Then, mice are individually suspended by tail with clamp (2 cm from the tip of the end) in a box (25 cm×25 cm×30 cm) with the head 5 cm to the bottom. Testing is carried out in a darkened room with minimal background noise. All animals are suspended for total 6 min, and the duration of immobility is observed and measured during the final 4-min interval of the test. All test sessions are recorded by a video camera positioned directly above the box. Two competent observers blind to treatment scored the videotapes. Mice consider immobile only when they hung passively and completely motionless. The animals are used only once in this test. All TSTs are performed between 11:00 A.M. and 14:00 P.M.
References

[1]. Ong SL, et al. Porcine Pancreatic Lipase Inhibitory Agent Isolated from Medicinal Herb and Inhibition Kinetics of Extracts from Eleusine indica (L.) Gaertner. J Pharm (Cairo). 2016;2016:8764274.

[2]. Tariq A, et al. Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites. Ann Clin Microbiol Antimicrob. 2016 Sep 20;15(1):52.

[3]. Zhao D, et al. Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri. Mar Drugs. 2016 Jun 28;14(7).
Density 1.0±0.1 g/cm3
Boiling Point 501.9±19.0 °C at 760 mmHg
Melting Point 139-142 ºC
Molecular Formula C29H50O
Molecular Weight 414.707
Flash Point 220.4±13.7 °C
Exact Mass 414.386169
PSA 20.23000
LogP 10.73
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.521
Storage condition -20°C
Water Solubility INSOLUBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WJ2600000
CHEMICAL NAME :
Stigmast-5-en-3-beta-ol
CAS REGISTRY NUMBER :
83-46-5
LAST UPDATED :
199706
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C29-H50-O
MOLECULAR WEIGHT :
414.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30 mg/kg
SEX/DURATION :
female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 46,461,1976
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H302-H315-H319-H331-H336-H351-H361d-H372
Precautionary Statements P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R38
Safety Phrases S22-S24/25-S36
RIDADR UN 1888 6.1/PG 3
WGK Germany 3
RTECS WJ2600000

Chemsrc provides CAS#:83-46-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 83-46-5 | Chemsrc address: https://m.chemsrc.com/en/baike/749358.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved