Stigmasterol
Stigmasterol structure
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Common Name | Stigmasterol | ||
|---|---|---|---|---|
| CAS Number | 83-48-7 | Molecular Weight | 412.691 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 501.1±19.0 °C at 760 mmHg | |
| Molecular Formula | C29H48O | Melting Point | 165-167 °C(lit.) | |
| MSDS | USA | Flash Point | 219.4±13.7 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
Use of StigmasterolStigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | stigmasterol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. |
|---|---|
| Related Catalog | |
| Target |
MMP[1] |
| In Vitro | Preincubation of Stigmasterol to IL-1beta-treated cells shows significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE2 protein in human and mouse. Stigmasterol is also capable of counteracting the IL-1beta-induced NF-κB pathway[1]. |
| Cell Assay | A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 501.1±19.0 °C at 760 mmHg |
| Melting Point | 165-167 °C(lit.) |
| Molecular Formula | C29H48O |
| Molecular Weight | 412.691 |
| Flash Point | 219.4±13.7 °C |
| Exact Mass | 412.370514 |
| PSA | 20.23000 |
| LogP | 10.21 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Storage condition | 2~8°C |
| Water Solubility | insoluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H319-H331-H336-H351-H361d-H372 |
| Precautionary Statements | P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn,Xi |
| Risk Phrases | R22 |
| Safety Phrases | S22-S24/25-S36/37 |
| RIDADR | UN 1888 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 2906199090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 6 | |
|---|---|
| DownStream 10 | |
CAS#:122795-00-0
CAS#:4651-48-3
CAS#:70813-67-1
CAS#:53603-94-4
CAS#:83787-28-4
CAS#:70813-69-3
CAS#:474-63-5
CAS#:915-05-9![[(3S,5S,8R,9S,10S,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate structure](https://image.chemsrc.com/caspic/340/2364-21-8.png)
CAS#:2364-21-8
CAS#:83-46-5
CAS#:83-45-4
CAS#:10211-88-8
CAS#:167958-89-6![[(3S,8S,9S,10R,13R,14S,17R)-17-[(E,2S,5S)-5-ethyl-6-methyl-hept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-naphthalen-1-ylcarbamate structure](https://image.chemsrc.com/caspic/422/80731-53-9.png)
CAS#:80731-53-9
CAS#:32212-73-0This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2906199090 |
|---|---|
| Summary | 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico.
BMC Complement Altern. Med. 15 , 244, (2015) The increasing numbers of people who use plant-based remedies as alternative or complementary medicine call for the validation of less known herbal formulations used to treat their ailments. Since Pue... |
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Analysis of triterpenoids and phytosterols in vegetables by thin-layer chromatography coupled to tandem mass spectrometry.
J. Chromatogr. A. 1381 , 229-38, (2015) Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mang... |
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Microwave-assisted derivatization: application to steroid profiling by gas chromatography/mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 8-13, (2014) Gas chromatography-mass spectrometry (GC-MS) remains as the gold-standard technique for the study of the steroid metabolome. A main limitation is the need of performing a derivatization step since inc... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (24S)-5,22-Stigmastadien-3b-ol |
| STIGMASTEROL (STIGMASTERIN) |
| (24S)-Stigmast-5,22-dien-3β-ol |
| STIGMASTEROL(P) |
| Wulzen anti-stiffness factor |
| Guinea-pig-anti-stiffness factor |
| SULFISOXAZOLE |
| Stigmasta-5,22-dien-3-ol, (3β,22E)- (9CI) |
| Stigmasta-5,22-dien-3β-ol |
| Stigmasterol |
| δ5,22-Stigmastadien-3β-ol |
| Anti-stiffness factor |
| (3β,22E)-Stigmasta-5,22-dien-3-ol |
| MFCD00003630 |
| Stigmasta-5,22-dien-3β-ol (8CI) |
| Stigmasta-5,22E-dien-3β-ol |
| isofucosterol |
| stigmasta-5,22-dien-3-b-ol |
| Stigmastero |
| EINECS 201-482-7 |
| Stigmasterin |
| (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-Ethyl-6-methyl-3-hepten-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| (3β,20R,22E,24S)-Stigmasta-5,22-dien-3-ol |
| 3b-Hydroxy-24-ethyl-D5,22-cholestadiene |
| δ5-Stigmasterol |
| 24S-ethylcholest-5,22-dien-3β-ol |
| stigmasta-5,22-dien-3-β-ol |
| β-Stigmasterol |
| (24S)-5,22-Stigmastadien-3β-ol |
| (3b,22E)-Stigmasta-5,22-dien-3-ol |
| 5,22-stigmastadien-3β-ol |
| (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,3E,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| PHYTOSTEROL |
| UNII-99WUK5D0Y8 |
| (24S)-24-Ethylcholesta-5,22-dien-3β-ol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of stigmasterol? |
| A: Polar surface area (PSA) of stigmasterol is 20.23000. |
| Q: What is the LogP of stigmasterol? |
| A: LogP of stigmasterol is 10.21. |
| Q: What is the English name of stigmasterol? |
| A: The English name of stigmasterol is stigmasterol. |
| Q: What is the melting point of stigmasterol? |
| A: Melting point of stigmasterol is 165-167 °C(lit.). |
| Q: What are the upstream materials of stigmasterol? |
| A: Related upstream materials(CAS) of stigmasterol: 122795-00-0;4651-48-3;70813-67-1;53603-94-4;83787-28-4;70813-69-3. |
| Q: What are the storage conditions for stigmasterol? |
| A: Storage conditions for stigmasterol: 2~8°C. |
| Q: What are the downstream products of stigmasterol? |
| A: Related downstream products(CAS) of stigmasterol: 474-63-5;4651-48-3;915-05-9;2364-21-8;83-46-5;83-45-4;10211-88-8;167958-89-6;80731-53-9;32212-73-0. |
| Q: What is the CAS number of stigmasterol? |
| A: CAS number of stigmasterol is 83-48-7. |
| Q: What is the boiling point of stigmasterol? |
| A: Boiling point of stigmasterol is 501.1±19.0 °C at 760 mmHg. |
| Q: What is the safety information for stigmasterol? |
| A: Safety information for stigmasterol: S22-S24/25-S36/37. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Henan Tianfu Chemical Co., Ltd. |