BioBioPha
China
Product Name: Methyl 4-hydroxybenzoate
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Methylparaben
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Methylparaben
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

99-76-3

99-76-3 structure

Name: Methyl 4-hydroxybenzoate
Chemical Name: methylparaben
CAS Number: 99-76-3
Molecular Formula: C₈H₈O₃
Molecular Weight: 152.147
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-09-09 18:09:01
Modify Date: 2026-06-30 13:20:40
Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].

Name	methylparaben
Synonyms	Methyl pahydroxybenzoate Methyl ester of p-hydroxybenzoic acid p-Hydroxybenzoic acid methyl ester, Methyl 4-hydroxybenzoate, Methyl paben methyl p-hydroxybenzoate METHYLPABEN,FCC RECHEM AL BF 0098 4-Hydroxybenzoic acid, methyl ester 4-(Carbomethoxy)phenol Mekkings M Methylparaben methylesterofp-hydroxybenzoicacid 4-(Methoxycarbonyl)phenol Methyl chemost Pidol Methyl parahydroxybenzoate Killitol Methyl chemosept Methyl-4-hydroxybenzoate p-Hydroxybenzoic acid methyl ester Past methyl para-hydroxybenzoate methylp-oxybenzoate Nigagin Methylpaben K0C3820.999mg/mg(dr) p-Cbomethoxyphenol Metoxyde Methyl 4-hydroxybenzoate,p-Hydroxybenzoic acid methyl ester, Methyl paben p-Hydroxybenzoic acid methyl ester, Methyl paben, Methylis pahydroxybenzoas METHYL-4-HYDROXYBENZOATE(SG) p-Hydroxybenzoic acid methyl ester, Methyl paben Methyl p-oxybenzoate femanumber2710 4-Hydroxy-benzoic acid methyl ester Methylpaben Metagin p-Hydroxybenzoic acid, methyl ester 4-HYDROXYLMETHYLBENZOATE METHYLPABEN,NF Lexgd M NipaginM MFCD00002352 Nipagin M Mastol methylpahydroxybenzoate component of Heb-Cort MC Astoform METHYL 4-HYDROXYBENZOATE WITH 4-hydroxy-benzoicacimethylester 4-Hydroxybenzoic acid methyl Methyl-p-hydroxybenzoate [-3] Benzoic acid, 4-hydroxy-, methyl ester Methyl p-hydroxybenzoate (methyl paben) Paben 4-HYDROXYBENZOICACIDMETHYLESTER(METHYLPABEN) methylchemost METHYLPABEN (METHYL 4-HYDROXYBENZOATE) Methyl 4-hydroxybenzoate, extra , Ph Eur, BP, NF, FCC, E Methyl Paraben Moldex 4-Hydroxybenzoic Acid Methyl Ester Benzoicacid,4-hydroxy-,methylester Methyl 4-hydroxybenzoate,p-Hydroxybenzoic acid methyl ester, Methyl paben, Methylis pahydroxybenzoas EINECS 202-785-7 NIPAGIN PLAIN METHYL-4-HYDROXYBENZOATE(RG) methylesterkyselinyp-hydroxybenzoove Abiol Methyl-4-hydroxybenzoat p-hydroxy-benzoicacimethylester Benzoic acid, p-hydroxy-, methyl ester Nipagin P-HYDROXYMETHYLBENZOATE Methylester kyseliny p-hydroxybenzoove p-Hydroxybenzoic methyl ester P-HYDROXYBENZOIC ACID METHYL ESTER Methyl parasept Tegosept M METHYL 4-HYDROXYBENZOATE / METHYLPABEN 4-Hydroxybenzoic acid methylester NIPAGIN Methylben

Description	Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Phenols
References	[1]. Soni MG, et al. Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem Toxicol. 2002 Oct;40(10):1335-73.

Density	1.2±0.1 g/cm3
Boiling Point	265.5±13.0 °C at 760 mmHg
Melting Point	125-128 °C(lit.)
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	116.4±12.6 °C
Exact Mass	152.047348
PSA	46.53000
LogP	1.87
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.547
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Freezing Point	131℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2450000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, methyl ester

CAS REGISTRY NUMBER :: 99-76-3

BEILSTEIN REFERENCE NO. :: 0509801

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QR DVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 500 mg/L

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (96),55,1978 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80461 No. of Facilities: 4469 (estimated) No. of Industries: 33 No. of Occupations: 50 No. of Employees: 57029 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80461 No. of Facilities: 15369 (estimated) No. of Industries: 94 No. of Occupations: 117 No. of Employees: 590361 (estimated) No. of Female Employees: 398916 (estimated)

Hazard Statements	H412
Precautionary Statements	P273
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi,Xn
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	UN 2769
WGK Germany	1
RTECS	DH2450000
HS Code	2918290000

Precursor 10
32122-11-5 17763-71-2 99768-12-4 67-56-1
99-96-7 123-08-0 24262-66-6 35750-24-4
133642-20-3 75915-29-6
DownStream 10
104605-71-2 110683-64-2 105960-29-0 110482-75-2
106047-17-0 106342-09-0 1090587-89-5 50909-50-7
3753-81-9 35826-59-6

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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1521953-71-8	1404194-37-1
1417566-44-9	1404194-61-1
54856-85-8	1047680-30-7
89909-48-8	1864002-98-1
1379347-80-4	876373-35-2