Top Suppliers:I want be here
Related CAS#:
75919-68-5 99-76-3
19438-10-9 35816-31-0
126429-92-3 165744-16-1
263555-88-0 119321-79-8
2479-75-6 6662-19-7
1535194-39-8 150673-50-0
195977-46-9 106833-80-1

99-76-3

99-76-3 structure
99-76-3 structure
  • Name: Methyl 4-hydroxybenzoate
  • Chemical Name: methylparaben
  • CAS Number: 99-76-3
  • Molecular Formula: C8H8O3
  • Molecular Weight: 152.147
  • Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
  • Create Date: 2018-09-09 18:09:01
  • Modify Date: 2025-08-21 12:15:46
  • Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].
Name methylparaben
Synonyms methyl p-hydroxybenzoate
4-Hydroxybenzoic acid, methyl ester
4-(Carbomethoxy)phenol
Mekkings M
Benzoic acid, 4-hydroxy-, methyl ester
Methylparaben
4-(Methoxycarbonyl)phenol
Methyl parahydroxybenzoate
Killitol
Methyl chemosept
Methyl-4-hydroxybenzoate
p-Hydroxybenzoic acid methyl ester
methyl para-hydroxybenzoate
4-Hydroxybenzoic Acid Methyl Ester
EINECS 202-785-7
Methyl 4-hydroxybenzoate
Benzoic acid, p-hydroxy-, methyl ester
Nipagin
4-Hydroxy-benzoic acid methyl ester
Metagin
p-Hydroxybenzoic acid, methyl ester
p-Hydroxybenzoic methyl ester
Methyl parasept
Tegosept M
4-Hydroxybenzoic acid methylester
MFCD00002352
Methyl Paraben
Description Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1].
Related Catalog
References

[1]. Soni MG, et al. Evaluation of the health aspects of methyl paraben: a review of the published literature. Food Chem Toxicol. 2002 Oct;40(10):1335-73.
Density 1.2±0.1 g/cm3
Boiling Point 265.5±13.0 °C at 760 mmHg
Melting Point 125-128 °C(lit.)
Molecular Formula C8H8O3
Molecular Weight 152.147
Flash Point 116.4±12.6 °C
Exact Mass 152.047348
PSA 46.53000
LogP 1.87
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.547
Stability Stable. Incompatible with strong oxidizing agents, strong bases.
Freezing Point 131℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DH2450000
CHEMICAL NAME :
Benzoic acid, p-hydroxy-, methyl ester
CAS REGISTRY NUMBER :
99-76-3
BEILSTEIN REFERENCE NO. :
0509801
LAST UPDATED :
199701
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C8-H8-O3
MOLECULAR WEIGHT :
152.16
WISWESSER LINE NOTATION :
QR DVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
960 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
500 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (96),55,1978 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80461 No. of Facilities: 4469 (estimated) No. of Industries: 33 No. of Occupations: 50 No. of Employees: 57029 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80461 No. of Facilities: 15369 (estimated) No. of Industries: 94 No. of Occupations: 117 No. of Employees: 590361 (estimated) No. of Female Employees: 398916 (estimated)
Hazard Statements H412
Precautionary Statements P273
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi,Xn
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25
RIDADR UN 2769
WGK Germany 1
RTECS DH2450000
HS Code 2918290000
HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:99-76-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 99-76-3 | Chemsrc address: https://m.chemsrc.com/en/baike/951920.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved