516-72-3

516-72-3 structure

Name: 20(S)-Hydroxycholesterol
Chemical Name: 20-hydroxycholesterol
CAS Number: 516-72-3
Molecular Formula: C₂₇H₄₆O₂
Molecular Weight: 402.65
Catalog: analytical chemistry Standard Forensic and veterinary standards
Create Date: 2018-02-18 08:00:00
Modify Date: 2024-01-19 00:33:10
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells[1][2].

Name	20-hydroxycholesterol
Synonyms	20α-Hydroxy Cholesterol 20ALPHA-HYDROXYCHOLESTEROL

Description	20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer
Target	EC50: 3 μM (hedgehog signaling pathway)[1]
References	[1]. Nachtergaele S, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol. 2012 Jan 8;8(2):211-20. [2]. Nedelcu D, et al, Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol. 2013 Sep;9(9):557-64.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3