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  • DC Chemicals Limited
  • China
  • Product Name: HE-2500
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

112859-71-9

112859-71-9 structure
112859-71-9 structure
  • Name: HE-2500
  • Chemical Name: Fluasterone
  • CAS Number: 112859-71-9
  • Molecular Formula: C19H27FO
  • Molecular Weight: 290.42
  • Catalog: Research Areas Cancer
  • Create Date: 2016-07-05 06:44:39
  • Modify Date: 2024-01-16 10:03:33
  • Fluasterone is a potent G6PD inhibitor with a Ki of 0.51 μM. Fluasterone has anti-inflammatory, cancer preventive, and anti-diabetic effects. Fluasterone is orally active[1][2][3].

Name Fluasterone
Synonyms 16-fluoro-5-androsten-17-one
Description Fluasterone is a potent G6PD inhibitor with a Ki of 0.51 μM. Fluasterone has anti-inflammatory, cancer preventive, and anti-diabetic effects. Fluasterone is orally active[1][2][3].
Related Catalog
Target

Ki: 0.51 μM (G6PD)[3]

In Vivo Fluasterone (0.2% and 0.3%; in diet for 39 days) 对糖尿病小鼠有抗高血糖作用[2]。 Fluasterone (200 μg/mouse; intradermal injection; once) 抑制 TPA 诱导的急性炎症和表皮增生作用[3]。 Animal Model: Male C57BL/KsJ db/db mice, diabetic model[2] Dosage: 0.2% and 0.3% Administration: In the diet for 39 days Result: Markedly reduced plasma glucose levels.
References

[1]. Schwartz AG, et al. Potential therapeutic use of dehydroepiandrosterone and structural analogs. Diabetes Technol Ther. 2001 Summer;3(2):221-4.  

[2]. Pashko LL, et al. Antihyperglycemic effect of dehydroepiandrosterone analogue 16 alpha-fluoro-5-androsten-17-one in diabetic mice. Diabetes. 1993 Aug;42(8):1105-8.  

[3]. Schwartz AG, et al. Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia and inflammation by the dehydroepiandrosterone analog 16alpha-fluoro-5-androsten-17-one and its reversal by NADPH liposomes. Cancer Lett. 2001 Jul 10;168(1):7-14.

Density 1.09g/cm3
Boiling Point 382.5ºC at 760mmHg
Molecular Formula C19H27FO
Molecular Weight 290.42
Flash Point 207.3ºC
Exact Mass 290.20500
PSA 17.07000
LogP 4.85640
Vapour Pressure 4.7E-06mmHg at 25°C
Index of Refraction 1.529