Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DL-Pyroglutamic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: C5H7NO3 DL-Pyroglutamic acid 149-87-1
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

149-87-1

149-87-1 structure

Name: 5-Oxopyrrolidine-2-carboxylic acid
Chemical Name: 5-oxoproline
CAS Number: 149-87-1
Molecular Formula: C₅H₇NO₃
Molecular Weight: 129.114
Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative
Create Date: 2018-07-02 15:05:38
Modify Date: 2026-06-30 11:04:21
DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action[1][2].

Name	5-oxoproline
Synonyms	MFCD00064322 C5H7NO3 DL-Pyroglutamic acid -1 (+/-)-2-PYRROLIDINONE-5-CBOXYLIC ACID L-Pidolic acid DL-PYROGLUTAMIC ACID Ajidew A 100 (S)-(-)-γ-Butyrolactam-γ-carboxylic acid DL-5-Oxoproline dl-Pyrrolidone cboxylic acid (+/-)-2-PYRROLIDONE-5-CBOXYLIC ACID LABOTEST-BB LT00005913 DL-5-OXO-2-PYRROLIDINECBOXYLIC ACID 5-Oxopyrrolidine-2-carboxylic Acid DL-5-PYRROLIDONE-2-CBOXYLIC ACID H-DL-PYR-OH L-5-Oxoproline DL-Pyroglutamic acid (S)-(−)-Pyroglutamic acid DL-Pyroglutamic acid //BP DL-A-PYROGLUTAMIC ACID a-Aminoglutaric Acid Lactam DL- pyroglutaMate 5-oxo-proline (S)-(−)-2-Pyrrolidone-5-carboxylic acid DL-2-Pyrrolidone-5-cboxylic acid (-)-Pyroglutamic acid 5-Oxo-L-proline 5-Pyrrolidinone-2-carboxylic acid Pyroglutamic acid and esters PCA EINECS 205-748-3 (2S)-5-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid DL-Pyroglutamic acid, 10 mM in DMSO 2-Pyrrolidone-5-carboxylic acid (S)-(-)-g-Butyrolactam-g-carboxylic Acid (±)-2-Pyrrolidone-5-cboxylic acid, DL-5-Oxo-2-pyrrolidinecboxylic acid DL-Pyr-OH DL-Pyroglutamic H-DL-Pyr-OH DL-2-Pyrrolidone-5-carboxylic acid (S)-(-)-2-pyrrolidone-5-carboxylic acid Pyrrolidonecarboxylic acid D,l-2-pyrrolidone-5-cboxylic acid PyroGlu DL-PyroglutamicAcid> DL-GLUTAMIC ACID LACTAM DL-5-Oxo-2-pyrrolidinecboxylic acid, DL-Pyroglutamic acid (^+)-2-Pyrrolidinone-5-cboxylicacid Pyroglutamic acid DL-2-PYRROLIDINONE-5-CBOXYLIC ACID (n)-2-pyrrolidinone-5-cboxylic acid DL-2-Pyrrolidone-5-cboxylic acidCNA10145 L-Glutamic Acid g-Lactam Cboglutamate impurity 6 D,l-2-Pyrrolidone-5-Carboxylic Acid DL-Glutamic Acid Lactam 2-Pyrrolidone-5-cboxylic Acid DL- pGlu-OH 2-Pyrrolidone-5-cboxylic acid DL-Proline, 5-oxo DL-PYR 5-OXO-DL-PROLINE Glutamic Acid Lactam 2-L-Pyrrolidone-5-carboxylic acid pidolic acid DL-Glutamic Acid Lactam 5-L-oxoproline

Description	DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	DL-Pyroglutamic acid results 50 and 100% inactivation of the antigen of 0.01-0.025% and 0.025-0.05%, respectively[1]. DL-Pyroglutamic acid is a possible glutamate antagonist, blocks glutamate miniature-end-plate potential in locust muscle-Druce and Bradford[2].
In Vivo	DL-Pyroglutamic acid (0.775 mM/L) completely abolishes the myoclonic jerks and EEG spikes in rats model of epileptic by cobalt implantation in the sensorimotor cerebral cortex[2].
References	[1]. Sugimoto Y, et al. N-alpha-Cocoyl-L-arginine ethyl ester, DL-pyroglutamic acid salt, as an inactivator of hepatitis B surface antigen. Antimicrob Agents Chemother. 1979 Sep;16(3):329-32.

Density	1.4±0.1 g/cm3
Boiling Point	453.1±38.0 °C at 760 mmHg
Melting Point	180-185ºC
Molecular Formula	C₅H₇NO₃
Molecular Weight	129.114
Flash Point	227.8±26.8 °C
Exact Mass	129.042587
PSA	66.40000
LogP	-2.39
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.512
Water Solubility	5.67 g/100 mL (20 ºC)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29337900

Precursor 9
56-86-0 138965-46-5 91871-28-2 59-30-3
617-65-2 1119-33-1 7391-23-3 109-76-2
3312-60-5
DownStream 10
4931-70-8 498-63-5 4931-66-2 6893-26-1
22348-32-9 63853-74-7 617-65-2 190783-99-4
16395-57-6 66183-71-9