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5985-28-4

5985-28-4 structure
5985-28-4 structure
  • Name: Synephrine hydrochloride
  • Chemical Name: 4-[1-hydroxy-2-(methylamino)ethyl]phenol,hydrochloride
  • CAS Number: 5985-28-4
  • Molecular Formula: C9H14ClNO2
  • Molecular Weight: 203.666
  • Catalog: Biochemical Inhibitor Neuronal Signaling Adrenergic Receptor Agonist
  • Create Date: 2018-04-23 08:00:00
  • Modify Date: 2024-01-04 11:03:13
  • Synephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most of its biological effects by acting as an agonist at adrenergic receptors.IC50 value:Target: adrenergic receptor agonistThere is some evidence that synephrine also has weak activity at 5-HT receptors, and that it interacts with TAAR1 (trace adrenergic amine receptors). d-synephrine inhibited the uptake of [3H]-norepinephrine with an IC50 = 5.8 μM; l-synephrine was less potent (IC50 = 13.5 μM). d-Synephrine also competitively inhibited the binding of nisoxetine[m] to rat brain cortical slices, with a Ki = 4.5 μM; l-synephrine was less potent (Ki = 8.2 μM). In experiments on the release of [3H]-norepinephrine from rat brain cortical slices, however, the l-isomer of synephrine was a more potent enhancer of the release (EC50 = 8.2 μM) than the d-isomer (EC50 = 12.3 μM). This enhanced release by l-synephrine was blocked by nisoxetine.
Name 4-[1-hydroxy-2-(methylamino)ethyl]phenol,hydrochloride
Synonyms UNII:EN5D1IH09S
DL-synephrine hydrochloride
EINECS 227-804-6
Synephrine HCl
4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride
MFCD00050566
Synephrine hydrochloride
4-[1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1)
2-methylamino-1-(4-hydroxyphenyl)-ethanol hydrochloride
Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, hydrochloride (1:1)
(+-)-1-(4-hydroxy-phenyl)-2-methylamino-ethanol,hydrochloride
Oxedrine hydrochloride
Ocuton (TN)
1-(4-Hydroxy-phenyl)-2-methylamino-aethanol,Hydrochlorid
Description Synephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most of its biological effects by acting as an agonist at adrenergic receptors.IC50 value:Target: adrenergic receptor agonistThere is some evidence that synephrine also has weak activity at 5-HT receptors, and that it interacts with TAAR1 (trace adrenergic amine receptors). d-synephrine inhibited the uptake of [3H]-norepinephrine with an IC50 = 5.8 μM; l-synephrine was less potent (IC50 = 13.5 μM). d-Synephrine also competitively inhibited the binding of nisoxetine[m] to rat brain cortical slices, with a Ki = 4.5 μM; l-synephrine was less potent (Ki = 8.2 μM). In experiments on the release of [3H]-norepinephrine from rat brain cortical slices, however, the l-isomer of synephrine was a more potent enhancer of the release (EC50 = 8.2 μM) than the d-isomer (EC50 = 12.3 μM). This enhanced release by l-synephrine was blocked by nisoxetine.
Related Catalog
References

[1]. Synephrine, From Wikipedia
Boiling Point 341.1ºC at 760 mmHg
Melting Point 147-150ºC
Molecular Formula C9H14ClNO2
Molecular Weight 203.666
Flash Point 163.4ºC
Exact Mass 203.071304
PSA 52.49000
LogP 1.83790
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DO7700000
CHEMICAL NAME :
Benzyl alcohol, p-hydroxy-alpha-((methylamino)methyl)-, hydrochloride
CAS REGISTRY NUMBER :
5985-28-4
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H13-N-O2.Cl-H
MOLECULAR WEIGHT :
203.69
WISWESSER LINE NOTATION :
QR DYQ1M1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 124,231,1927
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 124,231,1927
Hazard Codes Xi
HS Code 2922199090
Precursor  0

DownStream  1

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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