9-Methoxycamptothecine

Modify Date: 2024-01-02 15:52:12

9-Methoxycamptothecine Structure
9-Methoxycamptothecine structure
Common Name 9-Methoxycamptothecine
CAS Number 39026-92-1 Molecular Weight 378.378
Density 1.5±0.1 g/cm3 Boiling Point 773.1±60.0 °C at 760 mmHg
Molecular Formula C21H18N2O5 Melting Point 223-225 ºC
MSDS N/A Flash Point 421.4±32.9 °C

 Use of 9-Methoxycamptothecine


9-Methoxycamptothecin (MCPT), isolated from Nothapodytes foetida, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].

 Names

Name 9-Methoxycamptothecin
Synonym More Synonyms

 9-Methoxycamptothecine Biological Activity

Description 9-Methoxycamptothecin (MCPT), isolated from Nothapodytes foetida, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].
Related Catalog
Target

Topoisomerase[1]. Apoptosis[2].

References

[1]. Liao N, et al. 9-methoxycamptothecin from Nothapodytes foetida induces apoptosis in murine sarcoma S180 cells. Z Naturforsch C. 2011 Sep-Oct;66(9-10):471-6.

[2]. Wang H, et al. TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol. 2013 May;55:396-410.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 773.1±60.0 °C at 760 mmHg
Melting Point 223-225 ºC
Molecular Formula C21H18N2O5
Molecular Weight 378.378
Flash Point 421.4±32.9 °C
Exact Mass 378.121582
PSA 90.65000
LogP 2.00
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.723
Storage condition 2-8°C
Water Solubility Slightly soluble (2.7 g/L) (25 ºC)

 Synonyms

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (4S)-
10-methoxycamptothecin
9-methoxycamtothecin
(4S)-4-Ethyl-4-hydroxy-10-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Camptothecin,9-methoxy