- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: API-1(NSC 177223)
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Huang
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: API-1(NSC 177223)
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- DC Chemicals Limited
- China
- Product Name: API-1(NSC 177223)
- Price: ￥950.0/100mg ￥1750.0/250mg ￥3500.0/1g
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 5-amino-10-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-oxo-2,4,10-triazabicyclo[4.4.0]deca-1,3,5,8-tetraene-8-carboxamide
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
36707-00-3
36707-00-3 structure
- Name: API-1
- Chemical Name: 4-amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
- CAS Number: 36707-00-3
- Molecular Formula: C13H15N5O6
- Molecular Weight: 337.28800
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-05-08 22:20:33
- Modify Date: 2024-01-05 07:54:49
-
API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL)[1][2].
| Name | 4-amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide |
|---|---|
| Synonyms | NSC 177223 |
| Description | API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL)[1][2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.792g/cm3 |
|---|---|
| Boiling Point | 795.8ºC at 760 mmHg |
| Molecular Formula | C13H15N5O6 |
| Molecular Weight | 337.28800 |
| Flash Point | 435.1ºC |
| Exact Mass | 337.10200 |
| PSA | 186.81000 |
| Index of Refraction | 1.764 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 + P330 |
| RIDADR | UN 2811 6.1 / PGIII |
|
~28%
36707-00-3 |
| Literature: LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John Patent: WO2012/158197 A2, 2012 ; Location in patent: Page/Page column 107 ; |
|
~%
36707-00-3 |
| Literature: LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John Patent: WO2012/158197 A2, 2012 ; |
|
~%
36707-00-3 |
| Literature: LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John Patent: WO2012/158197 A2, 2012 ; |
| Precursor 3 | |
|---|---|
| DownStream 0 | |