API-1
Modify Date: 2024-01-05 07:54:49
API-1 structure
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Common Name | API-1 | ||
|---|---|---|---|---|
| CAS Number | 36707-00-3 | Molecular Weight | 337.28800 | |
| Density | 1.792g/cm3 | Boiling Point | 795.8ºC at 760 mmHg | |
| Molecular Formula | C13H15N5O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 435.1ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of API-1API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL)[1][2]. |
| Name | 4-amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL)[1][2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.792g/cm3 |
|---|---|
| Boiling Point | 795.8ºC at 760 mmHg |
| Molecular Formula | C13H15N5O6 |
| Molecular Weight | 337.28800 |
| Flash Point | 435.1ºC |
| Exact Mass | 337.10200 |
| PSA | 186.81000 |
| Index of Refraction | 1.764 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 + P330 |
| RIDADR | UN 2811 6.1 / PGIII |
|
~28%
API-1 CAS#:36707-00-3 |
| Literature: LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John Patent: WO2012/158197 A2, 2012 ; Location in patent: Page/Page column 107 ; |
|
~%
API-1 CAS#:36707-00-3 |
| Literature: LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John Patent: WO2012/158197 A2, 2012 ; |
|
~%
API-1 CAS#:36707-00-3 |
| Literature: LYNDOR BIOSCIENCES L.L.C.; AKINSANMI, Lawrence; KINCAID, John Patent: WO2012/158197 A2, 2012 ; |
![4-amino-2-methylsulfanyl-5-oxo-8-(tri-O-acetyl-β-D-ribofuranosyl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester structure](https://image.chemsrc.com/caspic/166/36707-03-6.png)
![Propanedioic acid,2-[[[6-amino-2-(methylthio)-4-pyrimidinyl]amino]methylene]-, 1,3-diethyl ester structure](https://image.chemsrc.com/caspic/366/36707-42-3.png)
![Propanedioicacid, 2-[[[6-(acetylamino)-2-(methylthio)-4-pyrimidinyl]amino]methylene]-,1,3-diethyl ester structure](https://image.chemsrc.com/caspic/328/36707-43-4.png)
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| NSC 177223 |