1359164-11-6

1359164-11-6 structure

Name: SR2211
Chemical Name: sr 2211
CAS Number: 1359164-11-6
Molecular Formula: C₂₆H₂₄F₇N₃O
Molecular Weight: 527.477
Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
Create Date: 2016-12-13 01:38:53
Modify Date: 2024-01-14 10:22:41
SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.

Name	sr 2211
Synonyms	1,1,1,3,3,3-Hexafluoro-2-(2-fluoro-4'-{[4-(4-pyridinylmethyl)-1-piperazinyl]methyl}-4-biphenylyl)-2-propanol [1,1'-Biphenyl]-4-methanol, 2-fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-

Description	SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Inflammation/Immunology
Target	IC50: ~320 nM (RORγ), Ki: 105 nM (RORγ)[1][2].
In Vitro	The treatment of EL4 with SR2211 represses the Il17 gene expression to a greater extent as compared to digoxin. Similarly, the expression of IL-23 receptor (Il23r) is significantly inhibited by SR2211 and digoxin, as has been previously reported. Treatment of EL-4 cells with SR2211 as well as a control digoxin results in significant inhibition of IL-17 intracellular staining as compared to vehicle treated cells[1].
References	[1]. Kumar N, et al. Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem Biol. 2012 Apr 20;7(4):672-7. [2]. Song Y, et al. Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. Eur J Med Chem. 2016 Jun 30;116:13-26.