82508-34-7

82508-34-7 structure

Name: Methylpseudolarate B
Chemical Name: Methyl (1R,7S,8S,9R)-7-acetoxy-9-[(1E,3E)-5-methoxy-4-methyl-5-oxo-1,3-pentadien-1-yl]-9-methyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-ene-4-carboxylate
CAS Number: 82508-34-7
Molecular Formula: C₂₃H₃₀O₆
Molecular Weight: 402.481
Catalog: Natural product Moss
Create Date: 2016-07-13 16:36:23
Modify Date: 2024-01-12 20:28:39
Methyl pseudolarate B, a natural diterpenoid, is a protein tyrosine phosphatase 1B (PTP1B) (Phosphatase) inhibitor with an IC50 value of 10.9 μM[1].

Name	Methyl (1R,7S,8S,9R)-7-acetoxy-9-[(1E,3E)-5-methoxy-4-methyl-5-oxo-1,3-pentadien-1-yl]-9-methyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-ene-4-carboxylate
Synonyms	Methyl (2E,4E)-5-[(1R,7S,8S,9R)-7-acetoxy-4,9-dimethyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methyl-2,4-pentadienoate 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic acid, 4a-(acetyloxy)-3,4,4a,5,6,9-hexahydro-3-[(1E,3E)-5-methoxy-4-methyl-5-oxo-1,3-pentadien-1-yl]-3-methyl-1-oxo-, methyl ester, (3R,4S,4aS,9aR)- 2,4-Pentadienoic acid, 5-[(3R,4S,4aS,9aR)-4a-(acetyloxy)-3,4,4a,5,6,9-hexahydro-3,7-dimethyl-1-oxo-1H-4,9a-ethanocyclohepta[c]pyran-3-yl]-2-methyl-, methyl ester, (2E,4E)- Methyl (1R,7S,8S,9R)-7-acetoxy-9-[(1E,3E)-5-methoxy-4-methyl-5-oxo-1,3-pentadien-1-yl]-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-ene-4-carboxylate

Description	Methyl pseudolarate B, a natural diterpenoid, is a protein tyrosine phosphatase 1B (PTP1B) (Phosphatase) inhibitor with an IC50 value of 10.9 μM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Metabolic Disease
Target	IC50: 10.9 μM (PTP1B)[1]
References	[1]. Chun Lei, et al. New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis. Fitoterapia. 2019 Nov;139:104414.

Hazard Codes	Xi