TCS 2002

Modify Date: 2024-01-08 11:26:40

TCS 2002 structure	Common Name	TCS 2002
	CAS Number	1005201-24-0	Molecular Weight	338.38000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₄N₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TCS 2002

GSK-3β inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. GSK-3β inhibitor 9 shows good pharmacokinetic profiles including favorable BBB penetration. GSK-3β inhibitor 9 can be used for the research of Alzheimer’s disease[1].

Name	2-methyl-5-[3-(4-methylsulfinylphenyl)-1-benzofuran-5-yl]-1,3,4-oxadiazole
Synonym	More Synonyms

Description	GSK-3β inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. GSK-3β inhibitor 9 shows good pharmacokinetic profiles including favorable BBB penetration. GSK-3β inhibitor 9 can be used for the research of Alzheimer’s disease[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3:35 nM (IC50)
In Vivo	GSK-3β inhibitor 9 (Compound 9b) (1-3 mg/kg;1-24 hours; GS rats andC57BL/6N mice) exhibits good pharmacokinetic profiles and favor able BBB permeability with AUC0-24h value is 734 ng•h/g and Kp value (ratio of brain and plasma) is 1.6[1]. Animal Model: IGS rats (male, 8 weeks old)[1] Dosage: 1 and 3mg/kg Administration: Intravenous injection and oral administration;for 1, 2, 4, 8, 24 hours. Result: 1.19 comp (S)-9b (S)-9c VDSS,iv (mL/kg) 1134 1650 CLtotal,iv (mL/min/kg) 27.4 28.4 Cmax,po (ng/mL) 396.9 289.6 AUC0-24 h,po (ng·h/mL) 1380.6 1229.1 MRTpo (h) 2.19 3.03 Fd (%) 72.8 65.5
References	[1]. Morihisa Saitoh, et al. 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. J Med Chem. 2009 Oct 22;52(20):6270-86.

Molecular Formula	C₁₈H₁₄N₂O₃S
Molecular Weight	338.38000
Exact Mass	338.07300
PSA	88.34000
LogP	5.06130

N/A

CAS#:1005201-23-9

~85%

TCS 2002

CAS#:1005201-24-0

Literature: Itoh, Fumio Patent: US2010/69381 A1, 2010 ; Location in patent: Page/Page column 102 ;

2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole

1,3,4-Oxadiazole,2-methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]

DC Chemicals Limited
China
Product Name: TCS-2002
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

TCS 2002 suppliers

TCS 2002 price

TCS 2002

Use of TCS 2002

Names

TCS 2002 Biological Activity

Chemical & Physical Properties

Synthetic Route

Synonyms