Levamlodipine

Modify Date: 2025-08-20 18:21:32

Levamlodipine Structure
Levamlodipine structure
Common Name Levamlodipine
CAS Number 103129-82-4 Molecular Weight 567.051
Density 1.2±0.1 g/cm3 Boiling Point 527.2±50.0 °C at 760 mmHg
Molecular Formula C20H25ClN2O5 Melting Point 102-104°C
MSDS N/A Flash Point 272.6±30.1 °C

 Use of Levamlodipine


Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina[1].

 Names

Name (S)-Amlodipine
Synonym More Synonyms

 Levamlodipine Biological Activity

Description Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina[1].
Related Catalog
Target

Calcium channel[1].

References

[1]. Jain R, et al. Polyaniline-graphene oxide nanocomposite sensor for quantification of calcium channel blocker levamlodipine. Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;65:205-14.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 527.2±50.0 °C at 760 mmHg
Melting Point 102-104°C
Molecular Formula C20H25ClN2O5
Molecular Weight 567.051
Flash Point 272.6±30.1 °C
Exact Mass 566.148987
PSA 99.88000
LogP 4.16
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.546
InChIKey HTIQEAQVCYTUBX-KRWDZBQOSA-N
SMILES CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl
Storage condition -20°C Freezer

 Safety Information

Hazard Codes Xi

 Synthetic Route

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Levamlodipine Structure

Levamlodipine

CAS#:103129-82-4

Literature: WO2008/51056 A1, ; Page/Page column 5; 7; 8 ;

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Levamlodipine Structure

Levamlodipine

CAS#:103129-82-4

Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

~64%

Levamlodipine Structure

Levamlodipine

CAS#:103129-82-4

Literature: Goldmann; Stoltefuss; Born Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3341 - 3344

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Levamlodipine Structure

Levamlodipine

CAS#:103129-82-4

Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

~%

Levamlodipine Structure

Levamlodipine

CAS#:103129-82-4

Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

~%

Levamlodipine Structure

Levamlodipine

CAS#:103129-82-4

Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

~%

Levamlodipine Structure

Levamlodipine

CAS#:103129-82-4

Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

~%

Levamlodipine Structure

Levamlodipine

CAS#:103129-82-4

Literature: WO2010/148191 A2, ; Page/Page column 45-49; 59 ;

~%

Levamlodipine Structure

Levamlodipine

CAS#:103129-82-4

Literature: Journal of Medicinal Chemistry, , vol. 35, # 18 p. 3341 - 3344

 Precursor & DownStream

Precursor  2

DownStream  0

 LevamlodipineBioassay

View more

Name: Binding affinity towards human ADRA2A in an in vitro assay with cellular components m...
Source: ChEMBL
Target: Alpha-2A adrenergic receptor
External Id: CHEMBL5291736
Name: Binding affinity towards human GABRA1 in an in vitro assay with cellular components m...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit gamma-2
External Id: CHEMBL5291799
Name: Binding affinity towards human PGR in an in vitro assay with cellular components meas...
Source: ChEMBL
Target: Progesterone receptor
External Id: CHEMBL5291863
Name: Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291792
Name: Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with ...
Source: ChEMBL
Target: Adenosine receptor A3
External Id: CHEMBL5291728
Name: Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay m...
Source: ChEMBL
Target: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
External Id: CHEMBL5291856
Name: Binding affinity towards human OPRM1 in an in vitro assay with cellular components me...
Source: ChEMBL
Target: Mu-type opioid receptor
External Id: CHEMBL5291855
Name: Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured...
Source: ChEMBL
Target: Alpha-1A adrenergic receptor
External Id: CHEMBL5291730
Name: Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas...
Source: ChEMBL
Target: Prothrombin
External Id: CHEMBL5291794
Name: Compound was evaluated for inhibition of human PDE4A in an in vitro cell free assay m...
Source: ChEMBL
Target: 3',5'-cyclic-AMP phosphodiesterase 4A
External Id: CHEMBL5291857
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 Synonyms

Norvasc
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-, benzenesulfonate (1:1)
l-Amlodipine
Levamlodipine Besylate Tablets
LevoaMlodipine
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
T6M DHJ B1O2Z CVO2 DR BG& EVO1 F1
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl Ester
Lodien
UNII:1J444QC288
3-Ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Levamlodipine
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate benzenesulfonate (1:1)
Amlodipine
Levoamlodipine Besylate
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate
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