Amlodipine

Modify Date: 2024-01-02 17:48:57

Amlodipine structure	Common Name	Amlodipine
	CAS Number	88150-42-9	Molecular Weight	408.876
	Density	1.2±0.1 g/cm3	Boiling Point	527.2±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₅ClN₂O₅	Melting Point	178-179ºC
	MSDS	N/A	Flash Point	272.6±30.1 °C

Use of Amlodipine

Amlodipine is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia.

Name	amlodipine
Synonym	More Synonyms

Description	Amlodipine is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
References	[1]. http://en.wikipedia.org/wiki/Amlodipine

Density	1.2±0.1 g/cm3
Boiling Point	527.2±50.0 °C at 760 mmHg
Melting Point	178-179ºC
Molecular Formula	C₂₀H₂₅ClN₂O₅
Molecular Weight	408.876
Flash Point	272.6±30.1 °C
Exact Mass	408.145203
PSA	99.88000
LogP	4.16
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.546
Storage condition	-20°C Freezer
Water Solubility	75.3 mg/L

Hazard Codes	Xi
HS Code	2942000000

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