Urocanic acid

Modify Date: 2024-01-04 15:21:24

Urocanic acid structure	Common Name	Urocanic acid
	CAS Number	104-98-3	Molecular Weight	138.124
	Density	1.4±0.1 g/cm3	Boiling Point	456.9±20.0 °C at 760 mmHg
	Molecular Formula	C₆H₆N₂O₂	Melting Point	226-228 °C(lit.)
	MSDS	Chinese USA	Flash Point	230.1±21.8 °C

Use of Urocanic acid

Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR).

Name	urocanic acid
Synonym	More Synonyms

Description	Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR).
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Others
Target	Human Endogenous Metabolite
In Vitro	Urocanic acid (UCA) is formed in the upper layers of the epidermis where filaggrin, a histidine-rich filamentous protein produced after caspase-14 cleavage of profilaggrin, is broken down by proteinases into component amino acids[1].
References	[1]. Gibbs NK, et al. Recent advances in urocanic acid photochemistry, photobiology and photoimmunology. Photochem Photobiol Sci. 2008 Jun;7(6):655-67.

Density	1.4±0.1 g/cm3
Boiling Point	456.9±20.0 °C at 760 mmHg
Melting Point	226-228 °C(lit.)
Molecular Formula	C₆H₆N₂O₂
Molecular Weight	138.124
Flash Point	230.1±21.8 °C
Exact Mass	138.042923
PSA	65.98000
LogP	0.01
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.674
Storage condition	2-8°C
Water Solubility	SLIGHTLY SOLUBLE

Urocanic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3425200

CHEMICAL NAME :: Imidazole-4-acrylic acid

CAS REGISTRY NUMBER :: 104-98-3

BEILSTEIN REFERENCE NO. :: 0081405

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H6-N2-O2

MOLECULAR WEIGHT :: 138.14

WISWESSER LINE NOTATION :: T5M CNJ D1U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 mmol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	NI3425200
HS Code	29332990

L-Histidine

CAS#:71-00-1

Urocanic acid

CAS#:104-98-3

Literature: Analytical Chemistry, , vol. 77, # 4 p. 1013 - 1019

Precursor 1
CAS#:71-00-1 L-Histidine
DownStream 4
CAS#:31434-93-2 1H-Imidazole-5-... CAS#:102676-60-8 Methyl 3-(1-Tri... CAS#:49549-75-9 3-(1H-imidazol-... CAS#:56662-92-1 5-ethenyl-1-met...

HS Code	29332990

Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine.

Pharm. Res. 32 , 2625-35, (2015)

An unknown UV 280 nm absorbing peak was observed by SEC for protein stability samples formulated in L-histidine during a stress stability study. Understanding the source would enhance the confidence i...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.

Eur. J. Med. Chem. 46 , 1483-98, (2011)

A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been s...

(2E)-3-(1H-Imidazol-4-yl)acrylic acid

urocanoic acid

(2E)-3-(1H-imidazol-4-yl)prop-2-enoic acid

(E)-3-(1H-imidazol-4-yl)acrylic acid

RARECHEM AL BK 0762

(Z/E)-3-(1H-imidazol-4-yl)-2-propenoic acid

3-(1H-imidazol-4-yl)prop-2-enoic acid

imidazoleacrylicacid

(E)-3-(1H-imidazol-4-yl)-2-propenoic acid

3-imidazol-4-ylacrylic

Urocanate

4-Imidazoleacrylic Acid

2-Propenoic acid, 3-(1H-imidazol-4-yl)-, (2E)-

UROCANINIC ACID

Trans-Urocanic acid

(E)-3-(1H-Imidazol-5-yl)-2-propenoic acid

3-(1H-Imidazol-4-yl)acrylic acid

Urocanic caid

Urocanic acid

3-imidazol-4-yl-acrylic acid

2-propenoic acid, 3-(1H-imidazol-5-yl)-, (2E)-

urosanic acid

4-imidazoleacrylate

MFCD00005203

(2E)-3-(1H-Imidazol-5-yl)acrylic acid

EINECS 203-258-4

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Urocanic acid
Price:
Purity: 98.0%
Stocking Period: Inquiry
Contact: Tom

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Urocanic acid
Price: ￥818.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Urocanic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

Urocanic acid suppliers

Price: ￥125.4/1g

Reference only. check more Urocanic acid price

Urocanic acid

Use of Urocanic acid

Names

Urocanic acid Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles33

Synonyms