CGP 20712 A
Modify Date: 2024-01-05 10:15:38
CGP 20712 A structure
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Common Name | CGP 20712 A | ||
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| CAS Number | 105737-62-0 | Molecular Weight | 590.56900 | |
| Density | N/A | Boiling Point | 764.8ºC at 760mmHg | |
| Molecular Formula | C24H29F3N4O8S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 416.3ºC | |
Use of CGP 20712 ACGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1]. |
| Name | CGP-20712A methanesulfonate salt |
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| Synonym | More Synonyms |
| Description | CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1]. |
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| Related Catalog | |
| Target |
IC50: 0.7 nM (β1-adrenoceptor)[1] |
| In Vitro | In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors[2]. |
| In Vivo | Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection[3]. |
| References |
| Boiling Point | 764.8ºC at 760mmHg |
|---|---|
| Molecular Formula | C24H29F3N4O8S |
| Molecular Weight | 590.56900 |
| Flash Point | 416.3ºC |
| Exact Mass | 590.16600 |
| PSA | 194.61000 |
| LogP | 3.99470 |
| Vapour Pressure | 9.69E-23mmHg at 25°C |
| Storage condition | 2-8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors.
Eur. J. Pharmacol. 130 , 137-139, (1986) CGP 20712 A (1-[2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino]-3- [4-(1-methyl-4-trifluoromethyl-2-imidazolyl) phenoxy]-2-propanol methanesulfonate), a specific beta 1-adrenoceptor antagonist, was test... |
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Beta-adrenoceptor subtypes in human coronary artery: desensitization of beta 2-adrenergic vasorelaxation by chronic beta 1-adrenergic stimulation in vitro.
J. Cardiovasc. Pharmacol. 25 , 134-141, (1995) We previously demonstrated that right atrial strips from patients treated with beta 1-selective antagonists exhibit sensitization of beta 2-adrenergic responses in vitro. We also showed that cardiac b... |
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