CGP 3466B maleate
Modify Date: 2024-01-03 02:57:30
CGP 3466B maleate structure
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Common Name | CGP 3466B maleate | ||
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| CAS Number | 200189-97-5 | Molecular Weight | 391.41700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H21NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CGP 3466B maleateOmigapil maleate (CGP3446B maleate) is an orally bioavailable apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD)[1]. Omigapil maleate, a GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice, suggesting that Omigapil maleate has the potential for the research of Alzheimer's disease[2]. |
| Name | N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine,(Z)-but-2-enedioic acid |
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| Synonym | More Synonyms |
| Description | Omigapil maleate (CGP3446B maleate) is an orally bioavailable apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD)[1]. Omigapil maleate, a GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice, suggesting that Omigapil maleate has the potential for the research of Alzheimer's disease[2]. |
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| Related Catalog | |
| Target |
Apoptosis[2] |
| In Vivo | Treatment of mice with Omigapil (0.1 mg/kg) results in improved muscle regeneration and increased force[1]. Animal Model: 12-week-old dyW/ mag mice[1] Dosage: 0.1 mg/kg Administration: For the first week of drug treatment, administered once daily by intraperitoneal injection. After weaning (3 weeks of age), applied once daily by oral gavage. Result: Reduced the muscle fibre loss. Many of the functional parameters were significantly improved by omigapil. |
| References |
| Molecular Formula | C23H21NO5 |
|---|---|
| Molecular Weight | 391.41700 |
| Exact Mass | 391.14200 |
| PSA | 87.07000 |
| LogP | 3.60970 |
| JHW 007 hydrochloride |
| Omigapil maleate |
| Dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine maleate |
| TCH-346 |
| CGP 3466B |
| UNII-3Q69BFZ4OP |
| N-(Dibenz(b,f)oxepin-10-ylmethyl)-N-methyl-N-(2-propynyl)amine monomaleic acid salt |