AL 8697

Modify Date: 2024-01-14 11:52:11

AL 8697 Structure
AL 8697 structure
Common Name AL 8697
CAS Number 1057394-06-5 Molecular Weight 402.41
Density N/A Boiling Point N/A
Molecular Formula C21H21F3N4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AL 8697


AL 8697 is a selective p38 MAPK inhibitor with IC50s of 6 nM and 82 nM for p38α and p38β, respectively[1].

 Names

Name 3-(3-tert-butyl-6,8-difluoro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide
Synonym More Synonyms

 AL 8697 Biological Activity

Description AL 8697 is a selective p38 MAPK inhibitor with IC50s of 6 nM and 82 nM for p38α and p38β, respectively[1].
Related Catalog
Target

p38α:6 nM (IC50)

p38β:82 nM ()

References

[1]. Balagué C, et al. Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br J Pharmacol. 2012 Jun;166(4):1320-32.

 Chemical & Physical Properties

Molecular Formula C21H21F3N4O
Molecular Weight 402.41
Exact Mass 402.16700
PSA 59.29000
LogP 4.70260

 Synonyms

al 8697
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