MAC13243

Modify Date: 2024-01-11 17:33:45

MAC13243 structure	Common Name	MAC13243
	CAS Number	1071638-38-4	Molecular Weight	442.40200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₅Cl₂N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MAC13243

MAC13243, an antibacterial agent, is a likely inhibitor of the bacterial lipoprotein targeting chaperone, LolA.IC50 Value: Target: AntibacterialMAC13243, a molecule that belongs to a new chemical class and that has a unique mechanism and promising activity against multidrug-resistant Pseudomonas aeruginosa. MAC13243 inhibits the function of the LolA protein and represents a new chemical probe of lipoprotein targeting in bacteria with promise as an antibacterial lead with Gram-negative selectivity.

Name	6-[(4-chlorophenyl)methylsulfanyl]-3-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dihydro-1H-1,3,5-triazine,hydrochloride
Synonym	More Synonyms

Description	MAC13243, an antibacterial agent, is a likely inhibitor of the bacterial lipoprotein targeting chaperone, LolA.IC50 Value: Target: AntibacterialMAC13243, a molecule that belongs to a new chemical class and that has a unique mechanism and promising activity against multidrug-resistant Pseudomonas aeruginosa. MAC13243 inhibits the function of the LolA protein and represents a new chemical probe of lipoprotein targeting in bacteria with promise as an antibacterial lead with Gram-negative selectivity.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Barker CA, et al. Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2426-31. [2]. Pathania R, et al. Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nat Chem Biol. 2009 Nov;5(11):849-56.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

References

[1]. Barker CA, et al. Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2426-31.

[2]. Pathania R, et al. Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nat Chem Biol. 2009 Nov;5(11):849-56.

Molecular Formula	C₂₀H₂₅Cl₂N₃O₂S
Molecular Weight	442.40200
Exact Mass	441.10400
PSA	71.39000
LogP	4.51360
Storage condition	2-8℃

cs-1183

MAC13243

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: MAC-13243
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $407/10mM*1mLinDMSO

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MAC13243

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