Lanreotide acetate salt

Modify Date: 2024-01-04 14:03:43

Lanreotide acetate salt Structure
Lanreotide acetate salt structure
 Common Name Lanreotide acetate salt
CAS Number 108736-35-2 Molecular Weight 1096.323
Density 1.4±0.1 g/cm3 Boiling Point 1508.2±65.0 °C at 760 mmHg
Molecular Formula C54H69N11O10S2 Melting Point N/A
MSDS N/A Flash Point 865.9±34.3 °C

 Use of Lanreotide acetate salt


Lanreotide (BIM 23014) is a somatostatin analogue with antineoplastic activity. Lanreotide can be used for the research of carcinoid syndrome[1][2].

 Names

Name Lanreotide
Synonym More Synonyms

 Lanreotide acetate salt Biological Activity

Description Lanreotide (BIM 23014) is a somatostatin analogue with antineoplastic activity. Lanreotide can be used for the research of carcinoid syndrome[1][2].
Related Catalog
In Vitro Lanreotide (BIM 23014) (100  nM; 24-48 h) combines with radiation increasing in apoptotic sub-G1 proportion[1]. Lanreotide results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide at concentrations of 1, 10, 100, and 1000  nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 is 57  nM[1]. Lanreotide inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro[2].
In Vivo Lanreotide (2.5-10mg/kg; s.c.; daily for 5 days) results in tumor growth inhibition[1]. Animal Model: Male nude mice, 8 weeks old and 20–25 g in body weight (GH3 tumor-bearing nude mice)[1] Dosage: 2.5, 5, 10 mg/kg Administration: Subcutaneous; daily for 5 days Result: Produced tumor growth inhibition.
References

[1]. Ning S, et al. Lanreotide promotes apoptosis and is not radioprotective in GH3 cells.Endocr Relat Cancer. 2009 Sep;16(3):1045-55.

[2]. Florio T, et al. Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.Clin Endocrinol (Oxf). 2003 Jul;59(1):115-28.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1508.2±65.0 °C at 760 mmHg
Molecular Formula C54H69N11O10S2
Molecular Weight 1096.323
Flash Point 865.9±34.3 °C
Exact Mass 1095.467041
PSA 405.68000
LogP 2.89
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.689

 Synonyms

B-naphthyl-D-ala-cys-tyr-D-trp*lys-val-cys-thr am
1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane-4-carboxamide, 10-(4-aminobutyl)-N-[1-(aminocarbonyl)-2-hydroxypropyl]-19-[[2-amino-3-(2-naphthalenyl)-1-oxopropyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-7-(1-methylethyl)-6,9,12,15,18-pentaoxo-
10-(4-Aminobutyl)-N-(1-amino-3-hydroxy-1-oxo-2-butanyl)-16-(4-hydroxybenzyl)-13-(1H-indol-3-ylmethyl)-7-isopropyl-19-{[3-(2-naphthyl)alanyl]amino}-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
Somatuline
AUTOGEL
ANGIOPEPTIN
IPSTYL
DC-13-116
10-(4-Aminobutyl)-N-(1-amino-3-hydroxy-1-oxobutan-2-yl)-16-(4-hydroxybenzyl)-13-(1H-indol-3-ylmethyl)-7-isopropyl-19-{[3-(2-naphthyl)alanyl]amino}-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-THR-NH2
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Chemsrc provides Lanreotide acetate salt(CAS#:108736-35-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Lanreotide acetate salt are included as well.>> amp version: Lanreotide acetate salt

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