Tuftsin acetate salt

Modify Date: 2024-01-08 11:44:22

Tuftsin acetate salt Structure
Tuftsin acetate salt structure
Common Name Tuftsin acetate salt
CAS Number 9063-57-4 Molecular Weight 500.59200
Density 1.48g/cm3 Boiling Point N/A
Molecular Formula C21H40N8O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tuftsin acetate salt


Tuftsin is a tetrapeptide. Tuftsin is a macrophage/microglial activator.

 Names

Name tuftsin
Synonym More Synonyms

 Tuftsin acetate salt Biological Activity

Description Tuftsin is a tetrapeptide. Tuftsin is a macrophage/microglial activator.
Related Catalog
In Vitro Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes[1]. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors[2].
References

[1]. Fridkin M, et al. Tuftsin: its chemistry, biology, and clinical potential. Crit Rev Biochem Mol Biol. 1989;24(1):1-40.

[2]. Wu M, et al. Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimentalautoimmune encephalomyelitis. PLoS One. 2012;7(4):e34933.

 Chemical & Physical Properties

Density 1.48g/cm3
Molecular Formula C21H40N8O6
Molecular Weight 500.59200
Exact Mass 500.30700
PSA 249.98000
LogP 0.44320

 Synthetic Route

 Synonyms

H-Thr-Lys-Pro-Arg-OH
THR-LYS-PRO-ARG 2ACOH 4H2O
Tuftsin hydrate acetate salt
Taftsin
L-Thr-L-Lys-L-Pro-L-Arg-OH
thr-Lys-Pro-Arg
Tuftsin Tuftsin acetate salt hydrate
L-Thr-L-Lys-L-Pro-L-Arg
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  • DC Chemicals Limited
  • China
  • Product Name: Tuftsin
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


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Price: $60/5mg

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