morpholine
morpholine structure
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Common Name | morpholine | ||
|---|---|---|---|---|
| CAS Number | 110-91-8 | Molecular Weight | 87.120 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 128.9±0.0 °C at 760 mmHg | |
| Molecular Formula | C4H9NO | Melting Point | -5 °C | |
| MSDS | Chinese USA | Flash Point | 35.6±0.0 °C | |
| Symbol |
GHS02, GHS05, GHS06 |
Signal Word | Danger | |
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Synthesis and antitumor activities of some new N1-(flavon-6-yl)amidrazone derivatives.
Arch. Pharm. (Weinheim) 347(6) , 415-22, (2014) A new series of N1-(flavon-6-yl)amidrazones were synthesized by reacting the hydrazonoyl chloride derived from 6-aminoflavone with the appropriate sec-cyclic amines. The antitumor activities of these compounds were evaluated on breast cancer (MCF-7) and leuke... |
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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Bioorg. Med. Chem. 15 , 6943-55, (2007) A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coefficient logK(p). The main objective was to find a limited set ... |
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The c-MET/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP/ABCG2 expression.
Mol. Pharmacol. 87(3) , 465-76, (2015) Overexpression of BCRP/ABCG2, a xenobiotic efflux transporter, is associated with anticancer drug resistance in tumors. Proto-oncogene c-MET induces cancer cell proliferation, motility, and survival, and its aberrant activation was found to be a prognostic fa... |
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Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: role of BK channels and cholinergic neurotransmission.
Am. J. Physiol. Cell Physiol. 309 , C107-16, (2015) Hydrogen sulfide (H2S) is a key signaling molecule regulating important physiological processes, including smooth muscle function. However, the mechanisms underlying H2S-induced detrusor smooth muscle (DSM) contractions are not well understood. This study inv... |
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In vivo transcription kinetics of a synthetic gene uninvolved in stress-response pathways in stressed Escherichia coli cells.
PLoS ONE 9(9) , e109005, (2014) The fast adaptation of Escherichia coli to stressful environments includes the regulation of gene expression rates, mainly of transcription, by specific and global stress-response mechanisms. To study the effects of mechanisms acting on a global level, we obs... |
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Effect of starch-beeswax coatings on quality parameters of blackberries (Rubus spp.).
J. Food Sci. Technol. 52 , 5601-10, (2015) There is increased interest in berry fruits due to health benefits, and maintenance of fruit quality for longer periods of time has been a priority. We previously found that starch based coatings applied on raspberries was associated to volatile compounds pro... |
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Quantitation of Synthetic Cannabinoids in Plant Materials Using High Performance Liquid Chromatography with UV Detection (Validated Method).
J. Forensic Sci. 60 , 1171-81, (2015) Plant based products laced with synthetic cannabinoids have become popular substances of abuse over the last decade. Quantitative analysis for synthetic cannabinoid content in the laced materials is necessary for health hazard assessments addressing overall e... |
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Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
J. Med. Chem. 52 , 3416-9, (2009) RPLC gains acceptance in pharmaceutical research for the rapid determination of lipophilicity but remains limited for the determination of partition coefficients of moderate to strong basic compounds under their neutral form because stationary phases are not ... |
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Design of more potent squalene synthase inhibitors with multiple activities
Bioorg. Med. Chem. 18 , 7402-12, (2010) Antihyperlipidemic morpholine derivatives ( 1– 6), combining several pharmacophore moieties, were evaluated in vitro and in vivo and optimized towards more active SQS inhibitors ( 7– 12). |
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Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism.
Biochem. Pharmacol. 97 , 111-21, (2015) Gefitinib (GEF), an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is widely used for the treatment of cancers, particularly non-small cell lung cancer. However, its clinical use is limited by multiple adverse effects associated with GE... |