ML-9 Free Base
Modify Date: 2024-01-05 20:00:46
ML-9 Free Base structure
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Common Name | ML-9 Free Base | ||
|---|---|---|---|---|
| CAS Number | 110448-31-2 | Molecular Weight | 324.82600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H17ClN2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML-9 Free BaseML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3]. |
| Name | 1-(5-chloronaphthalen-1-yl)sulfonyl-1,4-diazepane |
|---|---|
| Synonym | More Synonyms |
| Description | ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3]. |
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| Related Catalog | |
| In Vitro | ML9 (Free Base) (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death[2]. ML9 (Free Base) (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%[2]. Cell Viability Assay[1] Cell Line: Neonatal rat ventricular myocytes (NRVM) cells Concentration: 0, 10, 50 and 100 μM Incubation Time: 0, 1, 4, 8 and 24 hours Result: Decreased cell viability at 50–100 μM concentration. Apoptosis Analysis[1] Cell Line: Neonatal rat ventricular myocytes (NRVM) cells Concentration: 50 μM Incubation Time: 0, 1, 4, 8 hours Result: Induced cardiomyocyte death through necrosis and apoptosis. |
| References |
| Molecular Formula | C15H17ClN2O2S |
|---|---|
| Molecular Weight | 324.82600 |
| Exact Mass | 324.07000 |
| PSA | 57.79000 |
| LogP | 3.82470 |
| Hazard Codes | Xi |
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| Lopac-C-1172 |
| 1H-1,4-Diazepine,1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro |
| Tocris-0431 |