Propanenitrile,3,3'-iminobis-

Modify Date: 2024-01-02 22:03:03

Propanenitrile,3,3'-iminobis- structure	Common Name	Propanenitrile,3,3'-iminobis-
	CAS Number	111-94-4	Molecular Weight	123.15600
	Density	1.02 g/mL at 25 °C(lit.)	Boiling Point	205 °C25 mm Hg(lit.)
	Molecular Formula	C₆H₉N₃	Melting Point	-6 °C
	MSDS	Chinese USA	Flash Point	>230 °F
	Symbol	GHS07	Signal Word	Warning

Name	3,3'-iminodipropionitrile
Synonym	More Synonyms

Density	1.02 g/mL at 25 °C(lit.)
Boiling Point	205 °C25 mm Hg(lit.)
Melting Point	-6 °C
Molecular Formula	C₆H₉N₃
Molecular Weight	123.15600
Flash Point	>230 °F
Exact Mass	123.08000
PSA	59.61000
LogP	0.79426
Vapour Pressure	0.00019mmHg at 25°C
Index of Refraction	n20/D 1.47(lit.)
Stability	Stable, but moisture sensitive. Reaction with moisture may lead to a build up of pressure in sealed bottles. Combustible. Incompatible with strong oxidizing agents.

Propanenitrile,3,3'-iminobis- MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UG2975000

CHEMICAL NAME :: Propionitrile, 3,3'-iminodi-

CAS REGISTRY NUMBER :: 111-94-4

BEILSTEIN REFERENCE NO. :: 1746455

LAST UPDATED :: 199710

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C6-H9-N3

MOLECULAR WEIGHT :: 123.18

WISWESSER LINE NOTATION :: NC2M2CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,924,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,924,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,60,1949

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4000 ppm/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0522881

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 122,94,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555367

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ug/m3/6H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555367

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2520 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >10 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0522881 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 mg/kg/2W-I

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0522881

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg/3D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 13,575,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1109 mg/kg/3D-I

TOXIC EFFECTS :: Spinal Cord - other degenerative changes

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 19,622,1991 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 840 mg/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 21,407,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	UN 3334
WGK Germany	2
RTECS	UG2975000
HS Code	2926909090

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~99%

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Literature: The Research Foundation of State University of New York Patent: US6342492 B1, 2002 ; Location in patent: Page column 6 - 7 ;

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~46%

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Detail

Literature: Journal of the American Chemical Society, , vol. 66, p. 725,728 Org.Reactions, , vol. 5, p. 82,113 Tabelle I Journal of the American Chemical Society, , vol. 67, p. 1995 Journal of the American Chemical Society, , vol. 67, p. 93 Journal of the American Chemical Society, , vol. 69, p. 845,846

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Precursor 4
CAS#:107-13-1 Acrylonitrile CAS#:542-76-7 3-chloropropion... CAS#:7664-41-7 Ammonia CAS#:151-18-8 Z2CN
DownStream 10
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CAS#:109-76-2 1,3-Diaminopropane CAS#:143766-89-6 N-Boc-Iminodipr... CAS#:14247-04-2 4-Amino-1-benzy... CAS#:505-47-5 3,3'-Iminodipro...
CAS#:20373-91-5 3-Piperidinecar... CAS#:2372-77-2 N'-(3-aminoprop...

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Toxic neurofilamentous axonopathies -- accumulation of neurofilaments and axonal degeneration.

J. Intern. Med. 273(5) , 478-89, (2013)

A number of neurotoxic chemicals induce accumulation of neurofilaments in axonal swellings that appear at varying distances from the cell body. This pathology is associated with axonal degeneration of...

Butenenitriles have low axonopathic potential in the rat.

Toxicol. Lett. 200(3) , 187-93, (2011)

IDPN (3,3'-iminodipropionitrile) causes a neurofilamentous proximal axonopathy. This study addressed the hypothesis that the butenenitriles (allylnitrile, cis-crotononitrile and trans-crotononitrile) ...

Behavioral disturbances and hair cell loss in the inner ear following nitrile exposure in mice, guinea pigs, and frogs.

Toxicol. Sci. 96(1) , 123-32, (2007)

Several nitriles have been demonstrated to cause hair cell loss in the inner ear of the rat, but the susceptibility of other species to this toxic effect has not been investigated. Adult male Swiss mi...

EINECS 203-922-3

MFCD00001956

2341i.s.

3,3'-Iminodipropionitrile

BIS(CYANOETHYL)AMINE

HN(CH2CH2CN)2

3-[(2-cyanoethyl)amino]propanenitrile

3,3‘-Iminodipropionitrile

bis(2-cyanoethyl)amine

USAF a-8564

di-(2-cyanoethyl)amine

IDPN

BBCE

iminodipropionitrile

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Propanenitrile,3,3'-iminobis-
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Purity: 90.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Propanenitrile,3,3'-iminobis-
Price: ￥88.0/5ml
Purity: 98.0%
Delivery: 3 Day
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Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Propanenitrile,3,3'-iminobis-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Propanenitrile,3,3'-iminobis-

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