Propanenitrile,3,3'-iminobis-
Propanenitrile,3,3'-iminobis- structure
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Common Name | Propanenitrile,3,3'-iminobis- | ||
|---|---|---|---|---|
| CAS Number | 111-94-4 | Molecular Weight | 123.15600 | |
| Density | 1.02 g/mL at 25 °C(lit.) | Boiling Point | 205 °C25 mm Hg(lit.) | |
| Molecular Formula | C6H9N3 | Melting Point | -6 °C | |
| MSDS | Chinese USA | Flash Point | >230 °F | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Toxic neurofilamentous axonopathies -- accumulation of neurofilaments and axonal degeneration.
J. Intern. Med. 273(5) , 478-89, (2013) A number of neurotoxic chemicals induce accumulation of neurofilaments in axonal swellings that appear at varying distances from the cell body. This pathology is associated with axonal degeneration of different degrees. The clinical manifestation is most comm... |
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Butenenitriles have low axonopathic potential in the rat.
Toxicol. Lett. 200(3) , 187-93, (2011) IDPN (3,3'-iminodipropionitrile) causes a neurofilamentous proximal axonopathy. This study addressed the hypothesis that the butenenitriles (allylnitrile, cis-crotononitrile and trans-crotononitrile) have an IDPN-like axonopathic potential. First, male adult ... |
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Behavioral disturbances and hair cell loss in the inner ear following nitrile exposure in mice, guinea pigs, and frogs.
Toxicol. Sci. 96(1) , 123-32, (2007) Several nitriles have been demonstrated to cause hair cell loss in the inner ear of the rat, but the susceptibility of other species to this toxic effect has not been investigated. Adult male Swiss mice were administered (po) control vehicle, cis-crotononitri... |
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The neurotoxicity of iminodipropionitrile (IDPN) is ameliorated by copper.
Neurotoxicology 26(2) , 277-83, (2005) Iminodipropionitrile (IDPN) was given to rats on diets with normal copper levels, 5 ppm, and to rats on diets with high copper levels, 100 ppm. The former developed neurological symptoms, namely choreoathetoid head movements, circling and retropulsion, while ... |
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Influence of age on iminodipropionitrile-induced vestibular and neurobehavioral toxicities in rats.
Exp. Toxicol. Pathol. 55(2-3) , 181-6, (2003) A direct association between aging and drug-induced dyskinesia has been reported by several investigators. Iminiodipropionitrile (IDPN), a prototype nitrile compound produces a motor syndrome in rodents, which resembles neuroleptic drug induced dyskinesia. In... |
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Pentoxifylline attenuates iminodipropionitrile-induced behavioral abnormalities in rats.
Behav. Pharmacol. 20(4) , 356-60, (2009) This investigation was undertaken to study the effect of pentoxifylline (PTX) on iminodipropionitrile (IDPN)-induced behavioral abnormalities [excitation with choreiform and circling movements (ECC) syndrome] in rats. The animals were intraperitoneally inject... |
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Protective effect of hydrocortisone on iminodipropionitrile-induced neurotoxicity in rats.
Basic Clin Pharmacol Toxicol. 100(3) , 176-81, (2007) Occupational and environmental exposure of synthetic nitriles is of potential relevance to human health. Iminodipropionitrile (IDPN), a prototype nitrile toxin, has been shown to produce dyskinetic syndrome in rodents. This study reports the effect of concomi... |
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Sodium benzoate attenuates iminodipropionitrile-induced behavioral syndrome in rats.
Behav. Pharmacol. 15(8) , 585-8, (2004) This study reports the effects of the antioxidant sodium benzoate (SB) on iminodipropionitrile (IDPN)-induced excitation with choreiform and circling (ECC) syndrome in adult female Wistar rats. Rats in four different groups (n=8) received i.p. injections of S... |
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N-nitro-L-arginine, a nitric oxide synthase inhibitor, aggravates iminodipropionitrile-induced neurobehavioral and vestibular toxicities in rats.
Exp. Toxicol. Pathol. 64(7-8) , 791-6, (2012) Exposure of iminodipropionitrile (IDPN) to rodents produces permanent behavioral syndrome characterized by repetitive head movements, circling and back walking. Other synthetic nitriles of industrial importance such as crotonitrile and allylnitrile are also a... |
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Surface chemical conversion of 3-glycidoxypropyldimethylethoxysilane on hydroxylated silicon surface: FT-IR, contact angle and ellipsometry analysis.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 99 , 144-9, (2012) The chemical conversion of the top surface of 3-glycidoxypropyldimethylethoxysilane (GPDMES) on hyroxylated silicon surface has been studied as a function of reaction time. A multiple-step procedure was applied in this study. At first, GPDMES molecules were s... |