7,3',4'-Trihydroxy-3-benzyl-2H-chroMene

Modify Date: 2024-01-08 13:17:53

7,3',4'-Trihydroxy-3-benzyl-2H-chroMene structure	Common Name	7,3',4'-Trihydroxy-3-benzyl-2H-chroMene
	CAS Number	1111897-60-9	Molecular Weight	270.280
	Density	1.4±0.1 g/cm3	Boiling Point	540.8±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	280.9±30.1 °C

Use of 7,3',4'-Trihydroxy-3-benzyl-2H-chroMene

7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus[1][2].

Name	4-[(7-hydroxy-2H-chromen-3-yl)methyl]benzene-1,2-diol
Synonym	More Synonyms

Description	7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	IC50: 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5 µM [H9N2][1].
In Vitro	7,3',4'-Trihydroxy-3-benzyl-2H-chromene 具有有效的 NAs 抑制活性，IC50 值分别为 34.6 µM [H1N1]、39.5 µM [ H3N2] 和 50.5 µM [H9N2][1]。
References	[1]. Hyung Jae Jeong, et al. Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition. Biol Pharm Bull. 2012;35(5):786-90. [2]. Huanxin Zhao, et al. A new homoisoflavan from Caesalpinia sappan. J Nat Med. 2008 Jul;62(3):325-7.

Density	1.4±0.1 g/cm3
Boiling Point	540.8±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₄O₄
Molecular Weight	270.280
Flash Point	280.9±30.1 °C
Exact Mass	270.089203
PSA	69.92000
LogP	3.24
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.702

HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%