Patomostat mesilate
Modify Date: 2024-01-10 20:02:02
Patomostat mesilate structure
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Common Name | Patomostat mesilate | ||
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| CAS Number | 114568-32-0 | Molecular Weight | 508.56800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H24N4O7S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Patomostat mesilatePatamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2]. |
| Name | [4-[2-(2,5-dioxopyrrolidin-1-yl)ethylsulfanyl]phenyl] 4-(diaminomethylideneamino)benzoate,methanesulfonic acid |
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| Synonym | More Synonyms |
| Description | Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2]. |
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| Related Catalog | |
| Target |
IC50: 39 nM (trypsin), 950 nM (plasmin) and 1.9 μM (thrombin)[1] |
| In Vivo | Patamostat mesylate (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner[1]. Patamostat mesylate (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis[1]. Patamostat mesylate (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats[2]. Animal Model: Male Wistar rats weighing about 350 g[2] Dosage: 2 mg/kg Administration: Continuous infusion per h for 1 h Result: Significantly improved the survival rate. |
| References |
| Molecular Formula | C21H24N4O7S2 |
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| Molecular Weight | 508.56800 |
| Exact Mass | 508.10900 |
| PSA | 213.63000 |
| LogP | 3.84800 |
| Hazard Codes | Xi |
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Patomostat mesilate CAS#:114568-32-0 |
| Literature: Nochi; Shimomura; Hattori; Sato; Miyake; Tanizawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2855 - 2857 |
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Patomostat mesilate CAS#:114568-32-0 |
| Literature: Nochi; Shimomura; Hattori; Sato; Miyake; Tanizawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2855 - 2857 |
|
~%
Patomostat mesilate CAS#:114568-32-0 |
| Literature: Nochi; Shimomura; Hattori; Sato; Miyake; Tanizawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2855 - 2857 |
| Patamostat mesylate |
| Patamostat mesilate |