Rabeprazole
Rabeprazole structure
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Common Name | Rabeprazole | ||
|---|---|---|---|---|
| CAS Number | 117976-89-3 | Molecular Weight | 359.443 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 603.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C18H21N3O3S | Melting Point | 202-204°C | |
| MSDS | N/A | Flash Point | 319.1±34.3 °C | |
Use of RabeprazoleRabeprazole is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds. |
| Name | rabeprazole |
|---|---|
| Synonym | More Synonyms |
| Description | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 603.9±65.0 °C at 760 mmHg |
| Melting Point | 202-204°C |
| Molecular Formula | C18H21N3O3S |
| Molecular Weight | 359.443 |
| Flash Point | 319.1±34.3 °C |
| Exact Mass | 359.130371 |
| PSA | 96.31000 |
| LogP | 1.83 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.655 |
| Storage condition | -20℃ |
|
~90%
Rabeprazole CAS#:117976-89-3 |
| Literature: US2009/5570 A1, ; Page/Page column 3-4 ; |
|
~90%
Rabeprazole CAS#:117976-89-3 |
| Literature: EP1992619 A1, ; Page/Page column 16 ; |
|
~5%
Rabeprazole CAS#:117976-89-3 |
| Literature: US2007/249662 A1, ; Page/Page column 5 ; |
|
~49%
Rabeprazole CAS#:117976-89-3 |
| Literature: US5948789 A1, ; US 5948789 A |
|
~59%
Rabeprazole CAS#:117976-89-3 |
| Literature: US5948789 A1, ; US 5948789 A |
|
~%
Rabeprazole CAS#:117976-89-3 |
| Literature: EP1921075 A2, ; Page/Page column 8 ; |
|
~75%
Rabeprazole CAS#:117976-89-3 |
| Literature: WO2006/24890 A1, ; Page/Page column 6-7 ; |
|
~%
Rabeprazole CAS#:117976-89-3 |
| Literature: EP1818331 A1, ; Page/Page column 6 ; |
![2-[[4-(3-methoxypropoxy)-3-methyl-1-oxidopyridin-1-ium-2-yl]methylsulfanyl]-1H-benzimidazole structure](https://image.chemsrc.com/caspic/365/924663-40-1.png)
![2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole(RabeprazoleImpurity) structure](https://image.chemsrc.com/caspic/037/117976-47-3.png)
| Precursor 8 | |
|---|---|
| DownStream 1 | |
CAS#:117976-90-6| Rebeprazole |
| 2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole |
| Pariprazole |
| 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole |
| 2-({[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfinyl)-1H-benzimidazole |
| MFCD00868879 |
| Rabeprazole |
| 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]- |
| 2-({[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole |
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